Particulate Matter Containing Environmentally Persistent Free Radicals and Adverse Infant Respiratory Health Effects: a Review

Overview

Journal J Biochem Mol Toxicol

Publisher Wiley

Specialties Biochemistry
Molecular Biology
Toxicology

Date 2013 Jan 3

PMID 23281110

Citations 32

Authors

Jordy Saravia

Greg I Lee

Slawo Lomnicki

Barry Dellinger

Stephania A Cormier

Affiliations

Soon will be listed here.

Abstract

The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are also at significant risk for exposure. Infants are affected differently than adults due to drastic immaturities, both physiologically and immunologically, and it is becoming apparent that they represent a critically understudied population. Highlighting our work funded by the ONES award, in this review we argue the understated importance of utilizing infant models to truly understand the etiology of PM-induced predisposition to severe, persistent lung disease. We also touch upon various mechanisms of PM-mediated respiratory damage, with a focus on the emerging importance of environmentally persistent free radicals (EPFRs) ubiquitously present in combustion-derived PM. In conclusion, we briefly comment on strengths/challenges facing current PM research, while giving perspective on how we may address these challenges in the future.

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