Oral Immunotherapy for Food Allergy: Towards a New Horizon

Overview

Journal Allergy Asthma Immunol Res

Date 2013 Jan 2

PMID 23277873

Citations 15

Authors

Evelyne Khoriaty

Dale T Umetsu

Affiliations

Soon will be listed here.

Abstract

Food allergy has increased dramatically in prevalence over the past decade in westernized countries, and is now a major public health problem. Unfortunately for patients with food allergy, there is no effective therapy beyond food allergen avoidance, and rapid medical treatment for accidental exposures. Recently, oral immunotherapy (OIT) has been investigated as a treatment for this problem. In this review, we will discuss the progress in developing OIT for food allergy, including a novel approach utilizing Xolair (anti-IgE monoclonal antibody, omalizumab) in combination with OIT. This combination may enhance both the safety and efficacy of oral immunotherapy, and could lead to a widely available and safe therapy for food allergy.

Citing Articles

Combined Effects of and Egg Oral Immunotherapy in a Mouse Model of Egg Allergy.

Kim B, Kim J, Jang A, Shin M Allergy Asthma Immunol Res. 2020; 12(4):701-711.

PMID: 32400134 PMC: 7225004. DOI: 10.4168/aair.2020.12.4.701.

Oral and sublingual immunotherapy for egg allergy.

Romantsik O, Tosca M, Zappettini S, Calevo M Cochrane Database Syst Rev. 2018; 4:CD010638.

PMID: 29676439 PMC: 6494514. DOI: 10.1002/14651858.CD010638.pub3.

IgE Sensitization Patterns to Commonly Consumed Foods Determined by Skin Prick Test in Korean Adults.

Kim S, Park H, Park K, Lee J, Park J J Korean Med Sci. 2016; 31(8):1197-201.

PMID: 27478328 PMC: 4951547. DOI: 10.3346/jkms.2016.31.8.1197.

Current Options for the Treatment of Food Allergy.

Lanser B, Wright B, Orgel K, Vickery B, Fleischer D Pediatr Clin North Am. 2015; 62(6):1531-49.

PMID: 26456449 PMC: 4970423. DOI: 10.1016/j.pcl.2015.07.015.

Oral immunotherapy and anti-IgE antibody treatment for food allergy.

Umetsu D, Rachid R, Schneider L World Allergy Organ J. 2015; 8(1):20.

PMID: 26185589 PMC: 4491881. DOI: 10.1186/s40413-015-0070-3.

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