Study of C-reactive Protein and Myocardial Infarction in the Indian Population

Overview

Journal Indian J Clin Biochem

Specialty Biochemistry

Date 2013 Jan 2

PMID 23277716

Citations 2

Authors

Kavita Shalia

Sudha Savant

Vijaya A Haldankar

Tulip Nandu

Poonam Pawar

Siddhi Divekar

V K Shah

Purvi Bhatt

Affiliations

Soon will be listed here.

Abstract

To analyse the association of high sensitivity C-reactive (hsCRP) protein levels and -717A/G single nucleotide polymorphism of CRP with acute myocardial infarction (AMI) in the Indian population. Study population included 100 MI cases wherein 32 patients had experienced previous MI (MI-Group-1), 68 MI cases were recruited at presentation (MI-Group-2) and equal number of age and gender matched healthy individuals. hsCRP levels were determined by ELISA and genotyping of -717A/G was carried out by polymerase chain reaction-based restriction digestion method. The -717A/G genotypes did not influence hsCRP level and their distribution did not differ between groups. However, in the present study hsCRP demonstrated significant correlation with BMI in controls of both the genders and with triglycerides in females of AMI at presentation who otherwise are with low risk profile. Identifying traditional risk factors associated with inflammation may help in controlling the acute event.

Citing Articles

High sensitivity C-reactive protein (hsCRP) & cardiovascular disease: An Indian perspective.

Kamath D, Xavier D, Sigamani A, Pais P Indian J Med Res. 2015; 142(3):261-8.

PMID: 26458341 PMC: 4669860. DOI: 10.4103/0971-5916.166582.

Genetic Association Studies Reporting on Variants in the C-Reactive Protein Gene and Coronary Artery Disease: A Meta-Analysis.

Shi Y, Zhang J, Tan C, Xu W, Sun Q, Li J Medicine (Baltimore). 2015; 94(32):e1131.

PMID: 26266345 PMC: 4616666. DOI: 10.1097/MD.0000000000001131.

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