Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age

Overview

Journal Biochem Genet

Specialty Molecular Biology

Date 2013 Jan 1

PMID 23274712

Citations 10

Authors

Agata Sakowicz

Wojciech Fendler

Malgorzata Lelonek

Bartosz Sakowicz

Tadeusz Pietrucha

Affiliations

Soon will be listed here.

Abstract

This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR-RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups.

Citing Articles

Multi-modal transcriptomics: integrating machine learning and convolutional neural networks to identify immune biomarkers in atherosclerosis.

Chen H, Lai H, Chi H, Fan W, Huang J, Zhang S Front Cardiovasc Med. 2024; 11:1397407.

PMID: 39660117 PMC: 11628520. DOI: 10.3389/fcvm.2024.1397407.

Relationship between the AGT M235T genetic variant and the characteristics and prognosis of coronary atherosclerosis in patients with acute myocardial infarction.

Tran D, Duc Do M, Le L, Thai T, Hoang S, Truong B Mol Biol Rep. 2024; 51(1):1072.

PMID: 39425811 DOI: 10.1007/s11033-024-09986-5.

gene polymorphisms and susceptibility to myocardial infarction: Evidence from meta-analysis and trial sequential analysis.

Samii A, Aslani S, Imani D, Razi B, Samaneh Tabaee S, Jamialahmadi T Int J Cardiol Heart Vasc. 2023; 49:101293.

PMID: 38035258 PMC: 10687297. DOI: 10.1016/j.ijcha.2023.101293.

Loss-of-function N178T variant of the human P2Y receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.

Horckmans M, Diaz Villamil E, Verdier C, Laurell H, Ruidavets J, De Roeck L Front Pharmacol. 2022; 13:1049696.

PMID: 36532779 PMC: 9755162. DOI: 10.3389/fphar.2022.1049696.

Genetic polymorphisms in early-onset myocardial infarction in a sample of Iraqi patients: a pilot study.

Mohammad A, Othman G, Saeed C, Al Allawi S, Gedeon G, Qadir S BMC Res Notes. 2020; 13(1):541.

PMID: 33228791 PMC: 7686715. DOI: 10.1186/s13104-020-05367-w.

References

Blankenberg S, Rupprecht H, Poirier O, Bickel C, Smieja M, Hafner G . Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation. 2003; 107(12):1579-85. DOI: 10.1161/01.CIR.0000058700.41738.12. View

Reny J, Laurendeau I, Fontana P, Bieche I, Dupont A, Remones V . The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers. Thromb Haemost. 2004; 91(2):248-54. DOI: 10.1160/TH03-09-0566. View

Yokoyama H, Tahara H, Emoto M, Fujiwara S, Araki T, Shinohara K . The K469E polymorphism of the intercellular adhesion molecule-1 gene is associated with plasma fibrinogen level in type 2 diabetes. Metabolism. 2005; 54(3):381-6. DOI: 10.1016/j.metabol.2004.10.002. View

Heywood D, Carter A, Catto A, Bamford J, Grant P . Polymorphisms of the factor VII gene and circulating FVII:C levels in relation to acute cerebrovascular disease and poststroke mortality. Stroke. 1997; 28(4):816-21. DOI: 10.1161/01.str.28.4.816. View

Libby P . Inflammation in atherosclerosis. Nature. 2002; 420(6917):868-74. DOI: 10.1038/nature01323. View

Dikmen M, Ozbabalik D, Gunes H, Degirmenci I, Bal C, Ozdemir G . Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms. Acta Neurol Scand. 2006; 113(5):307-14. DOI: 10.1111/j.1600-0404.2005.00556.x. View

Gnasso A, Motti C, Irace C, Carallo C, Liberatoscioli L, Bernardini S . Genetic variation in human stromelysin gene promoter and common carotid geometry in healthy male subjects. Arterioscler Thromb Vasc Biol. 2000; 20(6):1600-5. DOI: 10.1161/01.atv.20.6.1600. View

Doughty M, Mehta R, Bruckman D, Das S, Karavite D, Tsai T . Acute myocardial infarction in the young--The University of Michigan experience. Am Heart J. 2002; 143(1):56-62. DOI: 10.1067/mhj.2002.120300. View

Trabetti E, Biscuola M, Cavallari U, Malerba G, Girelli D, Olivieri O . On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease. Eur J Hum Genet. 2005; 14(1):127-30. DOI: 10.1038/sj.ejhg.5201513. View

10.

Zhou X, Huang J, Chen J, Su S, Chen R, Gu D . Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study. Thromb Haemost. 2004; 92(4):867-73. DOI: 10.1160/TH04-03-0192. View

11.

Wenzel K, Stahn R, Speer A, Denner K, Glaser C, Affeldt M . Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations. Biol Chem. 1999; 380(6):661-7. DOI: 10.1515/BC.1999.082. View

12.

Kluijtmans L, WHITEHEAD A . Methylenetetrahydrofolate reductase genotypes and predisposition to atherothrombotic disease; evidence that all three MTHFR C677T genotypes confer different levels of risk. Eur Heart J. 2001; 22(4):294-9. DOI: 10.1053/euhj.2000.2239. View

13.

Beyzade S, Zhang S, Wong Y, Day I, Eriksson P, Ye S . Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction. J Am Coll Cardiol. 2003; 41(12):2130-7. DOI: 10.1016/s0735-1097(03)00482-0. View

14.

Middendorf K, Gohring P, Huehns T, Seidel D, Steinbeck G, Nikol S . Prevalence of resistance against activated protein C resulting from factor V Leiden is significantly increased in myocardial infarction: investigation of 507 patients with myocardial infarction. Am Heart J. 2004; 147(5):897-904. DOI: 10.1016/j.ahj.2003.10.048. View

15.

Yang Y, Cheng L, Ripen N, He M, Chang Z, Wu T . Association of G+1688A polymorphism of platelet endothelial cell adhesion molecule-1 gene with myocardial infarction in the Chinese Han population. J Huazhong Univ Sci Technolog Med Sci. 2007; 27(5):520-3. DOI: 10.1007/s11596-007-0511-5. View

16.

Balogh E, Bereczky Z, Katona E, Koszegi Z, Edes I, Muszbek L . Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: a case-control study. Thromb Res. 2011; 129(2):133-8. DOI: 10.1016/j.thromres.2011.07.001. View

17.

Ye S . Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome. Cardiovasc Res. 2005; 69(3):636-45. DOI: 10.1016/j.cardiores.2005.07.015. View

18.

Doggen C, Cats V, Bertina R, Reitsma P, Vandenbroucke J, Rosendaal F . A genetic propensity to high factor VII is not associated with the risk of myocardial infarction in men. Thromb Haemost. 1998; 80(2):281-5. View

19.

Xuan C, Bai X, Gao G, Yang Q, He G . Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls. Arch Med Res. 2011; 42(8):677-85. DOI: 10.1016/j.arcmed.2011.11.009. View

20.

Thim T, Hagensen M, Bentzon J, Falk E . From vulnerable plaque to atherothrombosis. J Intern Med. 2008; 263(5):506-16. DOI: 10.1111/j.1365-2796.2008.01947.x. View