Genetic Features of Thyroid Hormone Receptors

Overview

Journal J Genet

Specialty Genetics

Date 2012 Dec 29

PMID 23271024

Citations 2

Authors

Maha Rebai

Imen Kallel

Ahmed Rebai

Affiliations

Soon will be listed here.

Abstract

Thyroid hormone receptors (TR) are prototypes of nuclear transcription factors that regulate the expression of target genes. These receptors play an important role in many physiological processes. Moreover, a dysfunction of these proteins is often implicated in several human diseases and malignancies. Here we report genetic variations and alterations of the TRs that have been described in the literature as well as their potential role in the development of some human diseases including cancers. The functional effects of some mutations and polymorphisms in TRs on disease susceptibility, especially on cancer risk, are now established. Therefore, further investigations are needed in order to use these receptors as therapeutic targets or as biological markers to decide on appropriate forms of treatment.

Citing Articles

Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene.

Lee J, Kim E Ann Pediatr Endocrinol Metab. 2015; 19(4):229-31.

PMID: 25654071 PMC: 4316411. DOI: 10.6065/apem.2014.19.4.229.

Cloning and identification of a novel thyroid hormone receptor β isoform expressed in the pituitary gland.

Zhao R, Sun B, Liu Y, Li J, Xiong W, Liang D Mol Cell Biochem. 2014; 389(1-2):141-50.

PMID: 24481752 DOI: 10.1007/s11010-013-1935-9.

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