Effects of Cerium Oxide Nanoparticles on the Growth of Keratinocytes, Fibroblasts and Vascular Endothelial Cells in Cutaneous Wound Healing

Overview

Journal Biomaterials

Specialty Biomedical Engineering

Date 2012 Dec 26

PMID 23266256

Citations 105

Authors

Srinivasulu Chigurupati

Mohamed R Mughal

Eitan Okun

Soumen Das

Amit Kumar

Michael McCaffery

Sudipta Seal

Mark P Mattson

Affiliations

Soon will be listed here.

Abstract

Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles.

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