Radiation and Immunotherapy: Renewed Allies in the War on Cancer

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2012 Dec 25

PMID 23264923

Citations 7

Authors

Steven K Seung

Brendan Curti

Marka Crittenden

Walter Urba

Affiliations

Soon will be listed here.

Abstract

Anticancer immunotherapy holds great promises, as long-term responses to interleukin-2 have been observed in metastatic melanoma and renal cell carcinoma patients. However, improving the relative low rates of such responses has constituted a great challenge. In our experience, high-dose radiation combined with interleukin-2 provided encouraging results that are worth exploring further.

Citing Articles

Trial Watch: Peptide-based anticancer vaccines.

Pol J, Bloy N, Buque A, Eggermont A, Cremer I, Sautes-Fridman C Oncoimmunology. 2015; 4(4):e974411.

PMID: 26137405 PMC: 4485775. DOI: 10.4161/2162402X.2014.974411.

Role of CD8-positive cells in radioimmunotherapy utilizing (177)Lu-mAbs in an immunocompetent rat colon carcinoma model.

Elgstrom E, Eriksson S, Ohlsson T, Nilsson R, Tennvall J EJNMMI Res. 2015; 5:3.

PMID: 25853009 PMC: 4385015. DOI: 10.1186/s13550-014-0079-6.

Radiation meets immunotherapy - a perfect match in the era of combination therapy?.

Soukup K, Wang X Int J Radiat Biol. 2015; 91(4):299-305.

PMID: 25630486 PMC: 4389701. DOI: 10.3109/09553002.2014.995383.

Radiation therapy combined with -based cancer vaccine synergize to enhance tumor control in the B16 melanoma model.

Lim J, Brockstedt D, Lord E, Gerber S Oncoimmunology. 2014; 3:e29028.

PMID: 25083327 PMC: 4106167. DOI: 10.4161/onci.29028.

Intricacies for posttranslational tumor-targeted cytokine gene therapy.

Cutrera J, Dibra D, Satelli A, Xia X, Li S Mediators Inflamm. 2013; 2013:378971.

PMID: 24369443 PMC: 3863455. DOI: 10.1155/2013/378971.

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