A Genomic Approach to the Cryptic Secondary Metabolome of the Anaerobic World

Overview

Journal Nat Prod Rep

Publisher Royal Society of Chemistry

Date 2012 Dec 25

PMID 23263685

Citations 39

Authors

Anne-Catrin Letzel

Sacha J Pidot

Christian Hertweck

Affiliations

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Abstract

A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted.

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