Treatment of Arterial Remodeling in Essential Hypertension

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2012 Dec 20

PMID 23250721

Citations 27

Authors

Marie Briet

Ernesto L Schiffrin

Affiliations

Soon will be listed here.

Abstract

Essential hypertension is associated with large and small vascular remodeling that impacts cardiovascular prognosis. Longitudinal follow-up of hypertensive patients has shown that large arterial stiffness decreases partly independently of blood pressure reduction, suggesting specific pharmacological effects of antihypertensive therapy. Inhibitors of the renin-angiotensin-aldosterone system are among the agents that have been shown to affect vascular remodeling to a greater degree. Lifestyle modifications, including exercise and weight reduction, also improve large and small vascular remodeling. New antihypertensive drugs, including neprilysin inhibitors associated with an angiotensin receptor blocker, aldosterone synthase inhibitors and new devices such as renal denervation and baroreceptor stimulation, may exert beneficial effects on vascular remodeling and are currently under evaluation.

Citing Articles

24-hour central blood pressure and immune system activation in adolescents with primary hypertension - a preliminary study.

Skrzypczyk P, Bujanowicz A, Ofiara A, Szyszka M, Panczyk-Tomaszewska M Cent Eur J Immunol. 2023; 47(2):160-167.

PMID: 36751390 PMC: 9894090. DOI: 10.5114/ceji.2022.117929.

Endoplasmic Reticulum Chemical Chaperone 3-Hydroxy-2-Naphthoic Acid Reduces Angiotensin II-Induced Vascular Remodeling and Hypertension In Vivo and Protein Synthesis In Vitro.

Cicalese S, Torimoto K, Okuno K, Elliott K, Rizzo V, Hashimoto T J Am Heart Assoc. 2022; 11(23):e028201.

PMID: 36444851 PMC: 9851446. DOI: 10.1161/JAHA.122.028201.

Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?.

Li K, Wang Z, Ongachwa Machuki J, Li M, Wu Y, Niu M Front Physiol. 2022; 13:848867.

PMID: 35530510 PMC: 9075737. DOI: 10.3389/fphys.2022.848867.

Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects.

Ye C, Geng Z, Zhang L, Zheng F, Zhou Y, Zhu G Acta Pharmacol Sin. 2022; 43(10):2573-2584.

PMID: 35260820 PMC: 9525578. DOI: 10.1038/s41401-022-00875-w.

Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.

Russell J, Grisanti L, Brown S, Bailey C, Bender S, Chandrasekar B Cell Signal. 2021; 83:109993.

PMID: 33781845 PMC: 8204737. DOI: 10.1016/j.cellsig.2021.109993.

References

Briet M, Boutouyrie P, Laurent S, London G . Arterial stiffness and pulse pressure in CKD and ESRD. Kidney Int. 2012; 82(4):388-400. DOI: 10.1038/ki.2012.131. View

Pu Q, Brassard P, Javeshghani D, Iglarz M, Webb R, Amiri F . Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP. J Hypertens. 2008; 26(2):322-33. DOI: 10.1097/HJH.0b013e3282f16aaf. View

Ritt M, Harazny J, Ott C, Schneider M, Schlaich M, Michelson G . Wall-to-lumen ratio of retinal arterioles is related with urinary albumin excretion and altered vascular reactivity to infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine. J Hypertens. 2009; 27(11):2201-8. DOI: 10.1097/HJH.0b013e32833013fd. View

Ruilope L, Dukat A, Bohm M, Lacourciere Y, Gong J, Lefkowitz M . Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. Lancet. 2010; 375(9722):1255-66. DOI: 10.1016/S0140-6736(09)61966-8. View

Boutouyrie P, Achouba A, Trunet P, Laurent S . Amlodipine-valsartan combination decreases central systolic blood pressure more effectively than the amlodipine-atenolol combination: the EXPLOR study. Hypertension. 2010; 55(6):1314-22. DOI: 10.1161/HYPERTENSIONAHA.109.148999. View

Mitchell G, van Buchem M, Sigurdsson S, Gotal J, Jonsdottir M, Kjartansson O . Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study. Brain. 2011; 134(Pt 11):3398-407. PMC: 3212721. DOI: 10.1093/brain/awr253. View

De Ciuceis C, Porteri E, Rizzoni D, Corbellini C, La Boria E, Boari G . Effects of weight loss on structural and functional alterations of subcutaneous small arteries in obese patients. Hypertension. 2011; 58(1):29-36. DOI: 10.1161/HYPERTENSIONAHA.111.171082. View

Rizos E, Agouridis A, Elisaf M . The effect of statin therapy on arterial stiffness by measuring pulse wave velocity: a systematic review. Curr Vasc Pharmacol. 2010; 8(5):638-44. DOI: 10.2174/157016110792006950. View

Dengo A, Dennis E, Orr J, Marinik E, Ehrlich E, Davy B . Arterial destiffening with weight loss in overweight and obese middle-aged and older adults. Hypertension. 2010; 55(4):855-61. PMC: 2859827. DOI: 10.1161/HYPERTENSIONAHA.109.147850. View

10.

. Summary of the 2007 European Society of Hypertension (ESH) and European Society of Cardiology (ESC) guidelines for the management of arterial hypertension. Vasc Health Risk Manag. 2008; 3(6):783-95. PMC: 2350144. View

11.

Vaitkevicius P, Fleg J, Engel J, OConnor F, Wright J, Lakatta L . Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation. 1993; 88(4 Pt 1):1456-62. DOI: 10.1161/01.cir.88.4.1456. View

12.

Laurent S, Cockcroft J, van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D . Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006; 27(21):2588-605. DOI: 10.1093/eurheartj/ehl254. View

13.

Laurent S, Briet M, Boutouyrie P . Arterial stiffness as surrogate end point: needed clinical trials. Hypertension. 2012; 60(2):518-22. DOI: 10.1161/HYPERTENSIONAHA.112.194456. View

14.

Shahin Y, Alam Khan J, Chetter I . Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis. 2012; 221(1):18-33. DOI: 10.1016/j.atherosclerosis.2011.12.005. View

15.

De Ciuceis C, Porteri E, Rizzoni D, Rizzardi N, Paiardi S, Boari G . Structural alterations of subcutaneous small-resistance arteries may predict major cardiovascular events in patients with hypertension. Am J Hypertens. 2007; 20(8):846-52. DOI: 10.1016/j.amjhyper.2007.03.016. View

16.

Boari G, Rizzoni D, De Ciuceis C, Porteri E, Avanzi D, Platto C . Structural alterations in subcutaneous small resistance arteries predict changes in the renal function of hypertensive patients. J Hypertens. 2010; 28(9):1951-8. DOI: 10.1097/HJH.0b013e32833c2177. View

17.

Rizzoni D, Porteri E, Boari G, De Ciuceis C, Sleiman I, Muiesan M . Prognostic significance of small-artery structure in hypertension. Circulation. 2003; 108(18):2230-5. DOI: 10.1161/01.CIR.0000095031.51492.C5. View

18.

Blacher J, Guerin A, Pannier B, Marchais S, Safar M, London G . Impact of aortic stiffness on survival in end-stage renal disease. Circulation. 1999; 99(18):2434-9. DOI: 10.1161/01.cir.99.18.2434. View

19.

Souza F, Muxfeldt E, Fiszman R, Salles G . Efficacy of spironolactone therapy in patients with true resistant hypertension. Hypertension. 2009; 55(1):147-52. DOI: 10.1161/HYPERTENSIONAHA.109.140988. View

20.

Hashimoto J, Ito S . Central pulse pressure and aortic stiffness determine renal hemodynamics: pathophysiological implication for microalbuminuria in hypertension. Hypertension. 2011; 58(5):839-46. DOI: 10.1161/HYPERTENSIONAHA.111.177469. View