Pediatric Microcystic Meningioma: a Clinical, Histological, and Radiographic Case-based Review

Overview

Journal Childs Nerv Syst

Specialty Pediatrics

Date 2012 Dec 20

PMID 23250249

Citations 2

Authors

Jotham Manwaring

Amir Ahmadian

Stacie Stapleton

Ignacio Gonzalez-Gomez

Luis Rodriguez

Carolyn Carey

Gerald F Tuite

Affiliations

Soon will be listed here.

Abstract

Background: Microcystic meningioma (MM) is a World Health Organization grade I tumor that is rare in the pediatric population. Meningiomas account for approximately 2-4 % of all childhood central nervous system (CNS) tumors compared to approximately 20 % of all adult CNS tumors. The authors present one of the few confirmed cases of microcystic meningioma in a child and discuss the characteristic radiographic appearance and histological findings.

History: We report the case of an 11-year-old boy who presented with first-time seizure and imaging consistent with brain tumor. There was significant vasogenic edema within the entire right hemisphere, disproportionate to the size of the falcine-based tumor. Histopathological analysis revealed the microcystic subtype of meningioma.

Discussion: We review the radiographic characteristics, histopathological findings, and reported pediatric cases of MM in conjunction with our case.

Conclusion: MM has distinct radiographic characteristics (variable enhancement, lack of a dural tail, and disproportionate vasogenic edema) that can be misinterpreted in the pediatric population, suggesting a more aggressive tumor.

Citing Articles

Differentiating microcystic meningioma from atypical meningioma using diffusion-weighted imaging.

Xiaoai K, Qing Z, Lei H, Junlin Z Neuroradiology. 2020; 62(5):601-607.

PMID: 31996968 DOI: 10.1007/s00234-020-02374-3.

Histiocytic meningioma: A distinctive subtype of meningioma?.

Liu L, Stone J, Hoffpauir J, Xiong Z Intractable Rare Dis Res. 2014; 3(2):57-9.

PMID: 25343128 PMC: 4204537. DOI: 10.5582/irdr.2014.01007.

References

Michaud J, Gagne F . Microcystic meningioma. Clinicopathologic report of eight cases. Arch Pathol Lab Med. 1983; 107(2):75-80. View

Kremer S, Grand S, Remy C, Pasquier B, Benabid A, Bracard S . Contribution of dynamic contrast MR imaging to the differentiation between dural metastasis and meningioma. Neuroradiology. 2004; 46(8):642-8. DOI: 10.1007/s00234-004-1194-2. View

Kubota Y, Ueda T, Kagawa Y, Sakai N, Hara A . Microcystic meningioma without enhancement on neuroimaging--case report. Neurol Med Chir (Tokyo). 1997; 37(5):407-10. DOI: 10.2176/nmc.37.407. View

Tamiya T, Ono Y, Matsumoto K, Ohmoto T . Peritumoral brain edema in intracranial meningiomas: effects of radiological and histological factors. Neurosurgery. 2002; 49(5):1046-51; discussion 1051-2. DOI: 10.1097/00006123-200111000-00003. View

Im S, Wang K, Kim S, Oh C, Kim D, Hong S . Childhood meningioma: unusual location, atypical radiological findings, and favorable treatment outcome. Childs Nerv Syst. 2001; 17(11):656-62. DOI: 10.1007/s003810100507. View

Nishio S, Takeshita I, Morioka T, Fukui M . Microcystic meningioma: clinicopathological features of 6 cases. Neurol Res. 1994; 16(4):251-6. DOI: 10.1080/01616412.1994.11740236. View

Glasier C, Husain M, Chadduck W, Boop F . Meningiomas in children: MR and histopathologic findings. AJNR Am J Neuroradiol. 1993; 14(1):237-41. PMC: 8334465. View

Delannes M, Maire J, Sabatier J, Thillays F . [Stereotactic radiotherapy for intracranial meningioma]. Cancer Radiother. 2012; 16 Suppl:S79-89. DOI: 10.1016/j.canrad.2011.07.249. View

Grand S, Pasquier B, Hoffmann D, Krainik A, Ashraf A, Tropres I . Perfusion MR imaging and 1H spectroscopy: their role in the diagnosis of microcystic and lipomatous meningiomas. J Neuroradiol. 2009; 37(3):185-8. DOI: 10.1016/j.neurad.2009.08.008. View

10.

Kotecha R, Junckerstorff R, Lee S, Cole C, Gottardo N . Pediatric meningioma: current approaches and future direction. J Neurooncol. 2011; 104(1):1-10. DOI: 10.1007/s11060-010-0503-3. View

11.

Turgut M, Ozcan O, Bertan V . Meningiomas in childhood and adolescence: a report of 13 cases and review of the literature. Br J Neurosurg. 2000; 11(6):501-7. DOI: 10.1080/02688699745655. View

12.

Bloch O, Kaur G, Jian B, Parsa A, Barani I . Stereotactic radiosurgery for benign meningiomas. J Neurooncol. 2011; 107(1):13-20. DOI: 10.1007/s11060-011-0720-4. View

13.

Kotecha R, Pascoe E, Rushing E, Rorke-Adams L, Zwerdling T, Gao X . Meningiomas in children and adolescents: a meta-analysis of individual patient data. Lancet Oncol. 2011; 12(13):1229-39. DOI: 10.1016/S1470-2045(11)70275-3. View

14.

Simpson D . The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry. 1957; 20(1):22-39. PMC: 497230. DOI: 10.1136/jnnp.20.1.22. View

15.

Durand A, Labrousse F, Jouvet A, Bauchet L, Kalamarides M, Menei P . WHO grade II and III meningiomas: a study of prognostic factors. J Neurooncol. 2009; 95(3):367-375. DOI: 10.1007/s11060-009-9934-0. View

16.

Kleihues P, Burger P, Scheithauer B . The new WHO classification of brain tumours. Brain Pathol. 1993; 3(3):255-68. DOI: 10.1111/j.1750-3639.1993.tb00752.x. View

17.

Ng H, Tse C, Lo S . Microcystic meningiomas--an unusual morphological variant of meningiomas. Histopathology. 1989; 14(1):1-9. DOI: 10.1111/j.1365-2559.1989.tb02109.x. View

18.

Rushing E, Olsen C, Mena H, Rueda M, Lee Y, Keating R . Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients. J Neurosurg. 2005; 103(6 Suppl):489-95. DOI: 10.3171/ped.2005.103.6.0489. View

19.

Thuijs N, Uitdehaag B, van Ouwerkerk W, van der Valk P, Vandertop W, Peerdeman S . Pediatric meningiomas in The Netherlands 1974-2010: a descriptive epidemiological case study. Childs Nerv Syst. 2012; 28(7):1009-15. PMC: 3376254. DOI: 10.1007/s00381-012-1759-z. View

20.

Paek S, Kim S, Chang K, Park C, Kim J, Kim D . Microcystic meningiomas: radiological characteristics of 16 cases. Acta Neurochir (Wien). 2005; 147(9):965-72. DOI: 10.1007/s00701-005-0578-3. View