Second Malignant Neoplasms Following Radiotherapy

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2012 Dec 20

PMID 23249860

Citations 38

Authors

Sanath Kumar

Affiliations

Soon will be listed here.

Abstract

More than half of all cancer patients receive radiotherapy as a part of their treatment. With the increasing number of long-term cancer survivors, there is a growing concern about the risk of radiation induced second malignant neoplasm [SMN]. This risk appears to be highest for survivors of childhood cancers. The exact mechanism and dose-response relationship for radiation induced malignancy is not well understood, however, there have been growing efforts to develop strategies for the prevention and mitigation of radiation induced cancers. This review article focuses on the incidence, etiology, and risk factors for SMN in various organs after radiotherapy.

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References

Liauw S, Sylvester J, Morris C, Blasko J, Grimm P . Second malignancies after prostate brachytherapy: incidence of bladder and colorectal cancers in patients with 15 years of potential follow-up. Int J Radiat Oncol Biol Phys. 2006; 66(3):669-73. DOI: 10.1016/j.ijrobp.2006.05.016. View

Newhauser W, Durante M . Assessing the risk of second malignancies after modern radiotherapy. Nat Rev Cancer. 2011; 11(6):438-48. PMC: 4101897. DOI: 10.1038/nrc3069. View

Hodgson D, Gilbert E, Dores G, Schonfeld S, Lynch C, Storm H . Long-term solid cancer risk among 5-year survivors of Hodgkin's lymphoma. J Clin Oncol. 2007; 25(12):1489-97. DOI: 10.1200/JCO.2006.09.0936. View

Ron E . Ionizing radiation and cancer risk: evidence from epidemiology. Radiat Res. 1998; 150(5 Suppl):S30-41. View

Cairns J . Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proc Natl Acad Sci U S A. 2002; 99(16):10567-70. PMC: 124976. DOI: 10.1073/pnas.162369899. View

Reulen R, Frobisher C, Winter D, Kelly J, Lancashire E, Stiller C . Long-term risks of subsequent primary neoplasms among survivors of childhood cancer. JAMA. 2011; 305(22):2311-9. DOI: 10.1001/jama.2011.747. View

Bhatia S, Sklar C . Second cancers in survivors of childhood cancer. Nat Rev Cancer. 2003; 2(2):124-32. DOI: 10.1038/nrc722. View

OBrien M, Donaldson S, Balise R, Whittemore A, Link M . Second malignant neoplasms in survivors of pediatric Hodgkin's lymphoma treated with low-dose radiation and chemotherapy. J Clin Oncol. 2010; 28(7):1232-9. PMC: 4872329. DOI: 10.1200/JCO.2009.24.8062. View

Creutzberg C, Nout R, Lybeert M, Warlam-Rodenhuis C, Jobsen J, Mens J . Fifteen-year radiotherapy outcomes of the randomized PORTEC-1 trial for endometrial carcinoma. Int J Radiat Oncol Biol Phys. 2011; 81(4):e631-8. DOI: 10.1016/j.ijrobp.2011.04.013. View

10.

Prise K, OSullivan J . Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer. 2009; 9(5):351-60. PMC: 2855954. DOI: 10.1038/nrc2603. View

11.

Movsas B, Hanlon A, Pinover W, Hanks G . Is there an increased risk of second primaries following prostate irradiation?. Int J Radiat Oncol Biol Phys. 1998; 41(2):251-5. DOI: 10.1016/s0360-3016(97)00570-1. View

12.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

13.

Sasco A, Secretan M, Straif K . Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer. 2004; 45 Suppl 2:S3-9. DOI: 10.1016/j.lungcan.2004.07.998. View

14.

Tubiana M . Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review. Radiother Oncol. 2009; 91(1):4-15. DOI: 10.1016/j.radonc.2008.12.016. View

15.

Brenner D, Curtis R, Hall E, Ron E . Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer. 2000; 88(2):398-406. DOI: 10.1002/(sici)1097-0142(20000115)88:2<398::aid-cncr22>3.0.co;2-v. View

16.

Guibout C, Adjadj E, Rubino C, Shamsaldin A, Grimaud E, Hawkins M . Malignant breast tumors after radiotherapy for a first cancer during childhood. J Clin Oncol. 2004; 23(1):197-204. DOI: 10.1200/JCO.2005.06.225. View

17.

Suit H, Goldberg S, Niemierko A, Ancukiewicz M, Hall E, Goitein M . Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects. Radiat Res. 2007; 167(1):12-42. DOI: 10.1667/RR0527.1. View

18.

Zhang W, Becciolini A, Biggeri A, Pacini P, Muirhead C . Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy. Breast Cancer Res. 2011; 13(2):R38. PMC: 3219201. DOI: 10.1186/bcr2860. View

19.

Kendal W, Eapen L, MacRae R, Malone S, Nicholas G . Prostatic irradiation is not associated with any measurable increase in the risk of subsequent rectal cancer. Int J Radiat Oncol Biol Phys. 2006; 65(3):661-8. DOI: 10.1016/j.ijrobp.2005.11.013. View

20.

Stovall M, Smith S, Langholz B, Boice Jr J, Shore R, Andersson M . Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study. Int J Radiat Oncol Biol Phys. 2008; 72(4):1021-30. PMC: 3782859. DOI: 10.1016/j.ijrobp.2008.02.040. View