Menstrual Factors, Reproductive Factors and Lung Cancer Risk: a Meta-analysis

Overview

Journal Zhongguo Fei Ai Za Zhi

Specialties Oncology
Pulmonary Medicine

Date 2012 Dec 20

PMID 23249716

Citations 14

Authors

Yue Zhang

Zhihua Yin

Li Shen

Yan Wan

Baosen Zhou

Affiliations

Soon will be listed here.

Abstract

Background And Objective: Epidemiological studies have suggested that menstrual and reproductive factors may influence lung cancer risk, but the results are controversial. We therefore carried out a meta-analysis aiming to examine the associations of lung cancer in women with menstrual and reproductive factors.

Methods: Relevant studies were searched from PubMed database, CNKI, WANFANG DATA and VIP INFORMATION up to January 2012, with no language restrictions. References listed from selected papers were also reviewed. We included studies that reported the estimates of relative risks (RRs) with 95% confidence intervals (CIs) for the association between menstrual and reproductive factors and lung cancer risk. The pooled RRs were calculated after the heterogeneity test with the software Stata 11, and publication bias and sensitivity were evaluated at the same time.

Results: Twenty-five articles, representing 24 independent studies, were included in this meta-analysis. Older age at menarche in North America women (RR=0.83; 95%CI: 0.73-0.94) was associated with a significant decreased risk of lung cancer. Longer length of menstrual cycle was also associated with decreased lung cancer risk (RR=0.72; 95%CI: 0.57-0.90). Other exposures were not significantly associated.

Conclusions: Our analysis provides evidence of the hypothesis that female sex hormones influence the risk of lung cancer in women, yet additional studies are warranted to extend this finding and to clarify the underlying mechanisms.

Citing Articles

Age at first sexual intercourse, age at menarche, and age at menopause: a mendelian randomization study on lung cancer risk.

Liu Y, Ying X, Li Y, Zhu X, Jing W, Wang X Transl Lung Cancer Res. 2024; 13(7):1718-1726.

PMID: 39118897 PMC: 11304150. DOI: 10.21037/tlcr-24-480.

Reproductive factors and risk of lung cancer among 300,000 Chinese female never-smokers: evidence from the China Kadoorie Biobank study.

Elbasheer M, Bohrmann B, Chen Y, Lv J, Sun D, Wu X BMC Cancer. 2024; 24(1):384.

PMID: 38532314 PMC: 10964706. DOI: 10.1186/s12885-024-12133-9.

Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity.

Blechter B, Wong J, Chien L, Shiraishi K, Shu X, Cai Q Br J Cancer. 2024; 130(8):1286-1294.

PMID: 38388856 PMC: 11014844. DOI: 10.1038/s41416-024-02592-z.

Reproductive Factors in Relation to Incidence of Lung and Colorectal Cancers in a Cohort of Norwegian Women: The HUNT Study.

Denos M, Sun Y, Brumpton B, Langhammer A, Chen Y, Mai X J Endocr Soc. 2022; 7(1):bvac175.

PMID: 36466004 PMC: 9710734. DOI: 10.1210/jendso/bvac175.

Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones.

Zeng H, Yang Z, Li J, Wen Y, Wu Z, Zheng Y BMC Cancer. 2021; 21(1):690.

PMID: 34112140 PMC: 8194027. DOI: 10.1186/s12885-021-08437-9.

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