Identification of Cytomegalovirus and Human Herpesvirus-6 DNA in a Patient with Corneal Endotheliitis

Overview

Journal Jpn J Ophthalmol

Specialty Ophthalmology

Date 2012 Dec 19

PMID 23247975

Citations 3

Authors

Hideaki Yokogawa

Akira Kobayashi

Natsuko Yamazaki

Kazuhisa Sugiyama

Affiliations

Soon will be listed here.

Abstract

Purpose: To report the case of a patient with unilateral corneal endotheliitis in which both cytomegalovirus (CMV) and human herpesvirus-6 (HHV6) DNA was identified in the aqueous humor.

Case: A 67-year-old man with corneal endotheliitis OD was referred to us for decreased visual acuity. Local corneal stromal edema, pigmented keratic precipitates, a coin-shaped lesion and minimal anterior chamber reaction were observed by slit-lamp biomicroscopy. Cells with owl's eye appearance in the endothelial cell layer were observed by in vivo laser confocal microscopy. The patient had rheumatoid arthritis, which was treated by oral prednisolone and intravenous abatacept. Polymerase chain reaction analysis of aqueous humor samples detected both CMV and HHV6 DNA, but not other HHVs. Treatment with topical ganciclovir and systemic valganciclovir resulted in a clear cornea.

Conclusions: A patient with corneal endotheliitis had both CMV and HHV6 DNA identified in the aqueous humor. Although both viruses were identified in this case, clinical manifestations resembled CMV corneal endotheliitis, and it was unclear whether HHV6 could affect the clinical course. Systemic abatacept and corticosteroid therapy might play a positive role in cases with both CMV and HHV6 DNA in this corneal endotheliitis.

Citing Articles

Management of cytomegalovirus corneal endotheliitis.

Wong A, Kua W, Young A, Wan K Eye Vis (Lond). 2021; 8(1):3.

PMID: 33441165 PMC: 7807491. DOI: 10.1186/s40662-020-00226-y.

Human Herpesvirus-6 corneal Endotheliitis after intravitreal injection of Ranibizumab.

Onda M, Niimi Y, Ozawa K, Shiraki I, Mochizuki K, Yamamoto T BMC Ophthalmol. 2019; 19(1):19.

PMID: 30651089 PMC: 6335734. DOI: 10.1186/s12886-019-1032-2.

A new era of uveitis: impact of polymerase chain reaction in intraocular inflammatory diseases.

Mochizuki M, Sugita S, Kamoi K, Takase H Jpn J Ophthalmol. 2016; 61(1):1-20.

PMID: 27787641 DOI: 10.1007/s10384-016-0474-9.

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