Autoantibodies in Chronic Idiopathic Urticaria and Nonurticarial Systemic Autoimmune Disorders

Overview

Journal Ann Allergy Asthma Immunol

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2012 Dec 19

PMID 23244655

Citations 16

Authors

Christine B Cho

Shahan A Stutes

Michelle L Altrich

Stacy P Ardoin

Gary Phillips

Princess U Ogbogu

Affiliations

Soon will be listed here.

Abstract

Background: Chronic idiopathic urticaria (CU) has been associated with other autoimmune diseases and basophil-activating autoantibodies to FcεRI or IgE. It is unknown whether patients with systemicautoimmune diseases have a similar prevalence of these autoantibodies.

Objective: To compare the prevalences of basophil-activating autoantibodies (elevated CU Index) in patients with CU, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Clinical characteristics and laboratory studies were examined for an association with the CU Index.

Methods: Adult patients, 27 with CU, 27 with RA, and 26 with SLE, and 20 healthy controls were compared on the basis of the CU Index panel, anti-IgE, and antithyroid antibodies.

Results: The CU Index values were significantly higher in the CU group when compared with the RA group but not when compared with the SLE group. 33% of CU, 23% of SLE, 3.7% of RA, and 15% of controls had apositive CU Index. Elevated antithyroid antibody levels did not correlate with a positive CU Index in any of the groups. An elevated CU Index in the SLE group was not associated with age, sex, ethnicity, disease severity, or history of atopy.

Conclusion: The CU Index values were elevated in patients with CU and SLE. The presence of these autoantibodies did not correlate with disease activity or presence of thyroid antibodies. Functional autoantibodies may not be specific for chronic idiopathic urticaria, and their role in nonurticarial systemic autoimmune diseases requires further investigation.

Citing Articles

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Prevalence, Clinical Manifestations, Treatment, and Clinical Course of Chronic Urticaria in Elderly: A Systematic Review.

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Chronic urticaria and thyroid autoimmunity: a meta-analysis of case-control studies.

Tienforti D, Di Giulio F, Spagnolo L, Castellini C, Totaro M, Muselli M J Endocrinol Invest. 2022; 45(7):1317-1326.

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