Successful Treatment of Pulmonary Hypertension with Beraprost and Sildenafil After Cord Blood Transplantation for Infantile Leukemia

Overview

Journal Int J Hematol

Specialty Hematology

Date 2012 Dec 18

PMID 23243005

Citations 5

Authors

Nozomu Kawashima

Masanobu Ikoma

Yuko Sekiya

Atsushi Narita

Nao Yoshida

Kimikazu Matsumoto

Tameo Hatano

Koji Kato

Affiliations

Soon will be listed here.

Abstract

Pulmonary hypertension (PH) is an infrequently reported complication after hematopoietic stem cell transplantation, and its etiology and therapeutic strategies, especially in infants, remain unclear. We report a case of severe PH that developed in an infant with acute leukemia following administration of busulfan as a preconditioner for cord blood transplantation; the case was successfully treated with sildenafil and beraprost, which to our knowledge is the first reported successful use of this regimen in PH following transplantation for infantile leukemia. From a review of all previous reports, use of busulfan in infants may raise the risk of developing PH, and unlike definitive pulmonary veno-occlusive disease, PH in this subgroup may be reversible by early detection and treatment.

Citing Articles

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Pulmonary veno-occlusive disease in childhood-a rare disease not to be missed.

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Toxicities of busulfan/melphalan versus carboplatin/etoposide/melphalan for high-dose chemotherapy with stem cell rescue for high-risk neuroblastoma.

Desai A, Heneghan M, Li Y, Bunin N, Grupp S, Bagatell R Bone Marrow Transplant. 2016; 51(9):1204-10.

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Resource Utilization and Toxicities After Carboplatin/Etoposide/Melphalan and Busulfan/Melphalan for Autologous Stem Cell Rescue in High-Risk Neuroblastoma Using a National Administrative Database.

Desai A, Seif A, Li Y, Getz K, Fisher B, Huang V Pediatr Blood Cancer. 2016; 63(5):901-7.

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Pediatric pulmonary arterial hypertension.

Wu D, Zhang H, Jing Z Curr Hypertens Rep. 2013; 15(6):606-13.

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References

Limsuwan A, Pakakasama S, Hongeng S . Reversible course of pulmonary arterial hypertension related to bone marrow transplantation. Heart Vessels. 2011; 26(5):557-61. DOI: 10.1007/s00380-010-0100-6. View

Lopes A . Pathophysiological basis for anticoagulant and antithrombotic therapy in pulmonary hypertension. Cardiovasc Hematol Agents Med Chem. 2006; 4(1):53-9. DOI: 10.2174/187152506775268794. View

Resten A, Maitre S, Humbert M, Rabiller A, Sitbon O, Capron F . Pulmonary hypertension: CT of the chest in pulmonary venoocclusive disease. AJR Am J Roentgenol. 2004; 183(1):65-70. DOI: 10.2214/ajr.183.1.1830065. View

Itoh T, Nagaya N, Fujii T, Iwase T, Nakanishi N, Hamada K . A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med. 2003; 169(1):34-8. DOI: 10.1164/rccm.200303-346OC. View

Shankar S, Choi J, Dermody T, Head D, Bunin N, Iannone R . Pulmonary hypertension complicating bone marrow transplantation for idiopathic myelofibrosis. J Pediatr Hematol Oncol. 2004; 26(6):393-7. DOI: 10.1097/00043426-200406000-00013. View

Bruckmann C, Lindner W, Roos R, Permanetter W, Haas R, Haworth S . Severe pulmonary vascular occlusive disease following bone marrow transplantation in Omenn syndrome. Eur J Pediatr. 1991; 150(4):242-5. DOI: 10.1007/BF01955521. View

Jodele S, Hirsch R, Laskin B, Davies S, Witte D, Chima R . Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Biol Blood Marrow Transplant. 2012; 19(2):202-7. DOI: 10.1016/j.bbmt.2012.08.022. View

Montani D, OCallaghan D, Savale L, Jais X, Yaici A, Maitre S . Pulmonary veno-occlusive disease: recent progress and current challenges. Respir Med. 2010; 104 Suppl 1:S23-32. DOI: 10.1016/j.rmed.2010.03.014. View

Bredius R, Ouachee M, van Brempt R, Bokenkamp R, Lankester A, Dolman K . Pulmonary hypertension in two severe combined immunodeficiency disease patients posthaematopoietic stem cell transplantation. Br J Haematol. 2004; 125(3):405-6. DOI: 10.1111/j.1365-2141.2004.04910.x. View

10.

Steward C, Pellier I, Mahajan A, Ashworth M, Stuart A, Fasth A . Severe pulmonary hypertension: a frequent complication of stem cell transplantation for malignant infantile osteopetrosis. Br J Haematol. 2003; 124(1):63-71. DOI: 10.1046/j.1365-2141.2003.04739.x. View

11.

Al-Hashmi S, Boels P, Zadjali F, Sadeghi B, Sallstrom J, Hultenby K . Busulphan-cyclophosphamide cause endothelial injury, remodeling of resistance arteries and enhanced expression of endothelial nitric oxide synthase. PLoS One. 2012; 7(1):e30897. PMC: 3267746. DOI: 10.1371/journal.pone.0030897. View

12.

Hosokawa K, Yamazaki H, Nishitsuji M, Kobayashi S, Takami A, Fujimura M . Pulmonary veno-occlusive disease following reduced-intensity allogeneic bone marrow transplantation for acute myeloid leukemia. Intern Med. 2012; 51(2):195-8. DOI: 10.2169/internalmedicine.51.6302. View

13.

Bunte M, Patnaik M, Pritzker M, Burns L . Pulmonary veno-occlusive disease following hematopoietic stem cell transplantation: a rare model of endothelial dysfunction. Bone Marrow Transplant. 2008; 41(8):677-86. DOI: 10.1038/sj.bmt.1705990. View