The Trend in Morning Levels of Salivary Cortisol in Children With ADHD During 6 Months of Methylphenidate Treatment
Overview
Affiliations
Objective: To determine the trend in cortisol levels in children with ADHD treated with methylphenidate (MPH) and nontreated healthy controls over a 6-month period.
Method: The morning salivary cortisol levels of 50 patients with ADHD (40 boys and 10 girls, mean age = 7.6 years) and 50 age- and gender-matched healthy controls were measured at baseline and at 1, 3, and 6 months from baseline. The neuropsychological performance of the ADHD patients was measured via administration of the Continuous Performance Test.
Results: The cortisol levels of ADHD patients increased significantly after 1 month of MPH treatment before decreasing to an intermediate level, but were significantly positively correlated with neuropsychological performance throughout the 6-month treatment period. The cortisol levels of the controls did not change significantly over the 6-month period.
Conclusion: MPH administration appears to positively influence the functioning of the hypothalamic-pituitary-adrenal axis in ADHD patients.
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Jue H, Fang-Fang L, Dan-Fei C, Nuo C, Chun-Lu Y, Ke-Pin Y Front Psychiatry. 2023; 14:1148759.
PMID: 37389173 PMC: 10303788. DOI: 10.3389/fpsyt.2023.1148759.
Pauli-Pott U, Skoluda N, Nater U, Becker K, Derz F, Kaspar E Eur Child Adolesc Psychiatry. 2023; 33(2):569-579.
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