The Chemokine Receptor CXCR2 and Coronavirus-induced Neurologic Disease

Overview

Journal Virology

Specialty Microbiology

Date 2012 Dec 11

PMID 23217621

Citations 6

Authors

Jason G Weinger

Brett S Marro

Martin P Hosking

Thomas E Lane

Affiliations

Soon will be listed here.

Abstract

Inoculation with the neurotropic JHM strain of mouse hepatitis virus (MHV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis in which virus preferentially replicates within glial cells while excluding neurons. Control of viral replication during acute disease is mediated by infiltrating virus-specific T cells via cytokine secretion and cytolytic activity, however sterile immunity is not achieved and virus persists resulting in chronic neuroinflammation associated with demyelination. CXCR2 is a chemokine receptor that upon binding to specific ligands promotes host defense through recruitment of myeloid cells to the CNS as well as protecting oligodendroglia from cytokine-mediated death in response to MHV infection. These findings highlight growing evidence of the diverse and important role of CXCR2 in regulating neuroinflammatory diseases.

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References

Held K, Glass W, Orlovsky Y, Shamberger K, Petley T, Branigan P . Generation of a protective T-cell response following coronavirus infection of the central nervous system is not dependent on IL-12/23 signaling. Viral Immunol. 2008; 21(2):173-88. PMC: 2570712. DOI: 10.1089/vim.2008.0014. View

Liu Y, Pu Y, Zhang X . Role of the mitochondrial signaling pathway in murine coronavirus-induced oligodendrocyte apoptosis. J Virol. 2005; 80(1):395-403. PMC: 1317518. DOI: 10.1128/JVI.80.1.395-403.2006. View

Belperio J, Keane M, Burdick M, Gomperts B, Xue Y, Hong K . CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury. J Immunol. 2005; 175(10):6931-9. DOI: 10.4049/jimmunol.175.10.6931. View

Castro R, Evans G, Jaszewski A, Perlman S . Coronavirus-induced demyelination occurs in the presence of virus-specific cytotoxic T cells. Virology. 1994; 200(2):733-43. PMC: 7130599. DOI: 10.1006/viro.1994.1237. View

Glass W, Hickey M, Hardison J, Liu M, Manning J, Lane T . Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J Immunol. 2004; 172(7):4018-25. DOI: 10.4049/jimmunol.172.7.4018. View

Weiss S, Navas-Martin S . Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev. 2005; 69(4):635-64. PMC: 1306801. DOI: 10.1128/MMBR.69.4.635-664.2005. View

MATTHEWS A, Weiss S, Paterson Y . Murine hepatitis virus--a model for virus-induced CNS demyelination. J Neurovirol. 2002; 8(2):76-85. PMC: 7095071. DOI: 10.1080/13550280290049534. View

Akwa Y, Hassett D, Eloranta M, Sandberg K, Masliah E, Powell H . Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration. J Immunol. 1998; 161(9):5016-26. View

Boyle E, McGeer P . Cellular immune response in multiple sclerosis plaques. Am J Pathol. 1990; 137(3):575-84. PMC: 1877509. View

10.

Savarin C, Stohlman S, Atkinson R, Ransohoff R, Bergmann C . Monocytes regulate T cell migration through the glia limitans during acute viral encephalitis. J Virol. 2010; 84(10):4878-88. PMC: 2863800. DOI: 10.1128/JVI.00051-10. View

11.

Walsh K, Lanier L, Lane T . NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis. J Virol. 2007; 82(6):3031-44. PMC: 2259000. DOI: 10.1128/JVI.02033-07. View

12.

Epstein L, Prineas J, Raine C . Attachment of myelin to coated pits on macrophages in experimental allergic encephalomyelitis. J Neurol Sci. 1983; 61(3):341-8. DOI: 10.1016/0022-510x(83)90167-3. View

13.

Holmes K . SARS-associated coronavirus. N Engl J Med. 2003; 348(20):1948-51. DOI: 10.1056/NEJMp030078. View

14.

Versteeg G, Bredenbeek P, van den Worm S, Spaan W . Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition. Virology. 2007; 361(1):18-26. PMC: 7103335. DOI: 10.1016/j.virol.2007.01.020. View

15.

Tran E, Hoekstra K, van Rooijen N, Dijkstra C, Owens T . Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J Immunol. 1998; 161(7):3767-75. View

16.

Carbajal K, Miranda J, Tsukamoto M, Lane T . CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination. Glia. 2011; 59(12):1813-21. PMC: 5025299. DOI: 10.1002/glia.21225. View

17.

Minagawa H, Takenaka A, Mohri S, Mori R . Protective effect of recombinant murine interferon beta against mouse hepatitis virus infection. Antiviral Res. 1987; 8(2):85-95. DOI: 10.1016/0166-3542(87)90079-9. View

18.

Wengner A, Pitchford S, Furze R, Rankin S . The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood. 2007; 111(1):42-9. PMC: 2575836. DOI: 10.1182/blood-2007-07-099648. View

19.

Gonzalez J, Bergmann C, Ramakrishna C, Hinton D, Atkinson R, Hoskin J . Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination. Am J Pathol. 2006; 168(3):796-804. PMC: 1606538. DOI: 10.2353/ajpath.2006.050496. View

20.

Filipovic R, Zecevic N . The effect of CXCL1 on human fetal oligodendrocyte progenitor cells. Glia. 2007; 56(1):1-15. DOI: 10.1002/glia.20582. View