Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-induced Hepatopathy in Mice

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2012 Dec 6

PMID 23213269

Citations 8

Authors

Teruaki Toyota

Takahiro Kataoka

Yuichi Nishiyama

Takehito Taguchi

Kiyonori Yamaoka

Affiliations

Soon will be listed here.

Abstract

We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol-induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol-induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol-induced hepatopathy in mice.

Citing Articles

Effects of low-dose/high-dose-rate X-irradiation on oxidative stress in organs following forced swim test and its combined effects on alcohol-induced liver damage in mice.

Naoe S, Fujimoto Y, Murakami K, Yukimine R, Tanaka A, Yamaoka K J Radiat Res. 2023; 64(4):635-643.

PMID: 37205845 PMC: 10354849. DOI: 10.1093/jrr/rrad030.

Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice.

Kataoka T, Ishida T, Naoe S, Kanzaki N, Sakoda A, Tanaka H J Radiat Res. 2022; 63(5):719-729.

PMID: 35818298 PMC: 9494542. DOI: 10.1093/jrr/rrac046.

Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy.

Yamaoka K, Kataoka T J Clin Biochem Nutr. 2022; 70(2):87-92.

PMID: 35400814 PMC: 8921726. DOI: 10.3164/jcbn.21-85.

Evaluation of the redox state in mouse organs following radon inhalation.

Kataoka T, Kanzaki N, Sakoda A, Shuto H, Yano J, Naoe S J Radiat Res. 2021; 62(2):206-216.

PMID: 33503655 PMC: 7948851. DOI: 10.1093/jrr/rraa129.

Radon Exposure-Therapeutic Effect and Cancer Risk.

Maier A, Wiedemann J, Rapp F, Papenfuss F, Rodel F, Hehlgans S Int J Mol Sci. 2021; 22(1).

PMID: 33396815 PMC: 7796069. DOI: 10.3390/ijms22010316.

References

Kataoka T, Sakoda A, Ishimori Y, Toyota T, Nishiyama Y, Tanaka H . Study of the response of superoxide dismutase in mouse organs to radon using a new large-scale facility for exposing small animals to radon. J Radiat Res. 2011; 52(6):775-81. DOI: 10.1269/jrr.10072. View

Kataoka T, Yamaoka K . Activation of biodefense system by low-dose irradiation or radon inhalation and its applicable possibility for treatment of diabetes and hepatopathy. ISRN Endocrinol. 2012; 2012:292041. PMC: 3302064. DOI: 10.5402/2012/292041. View

Yamaoka K, Mitsunobu F, Hanamoto K, Mori S, Tanizaki Y, Sugita K . Study on biologic effects of radon and thermal therapy on osteoarthritis. J Pain. 2004; 5(1):20-5. DOI: 10.1016/j.jpain.2003.09.005. View

Kataoka T, Mizuguchi Y, Yoshimoto M, Taguchi T, Yamaoka K . Inhibitory effects of prior low-dose x-irradiation on ischemia-reperfusion injury in mouse paw. J Radiat Res. 2007; 48(6):505-13. DOI: 10.1269/jrr.07060. View

Kojima S, Matsuki O, Nomura T, Kubodera A, Honda Y, Honda S . Induction of mRNAs for glutathione synthesis-related proteins in mouse liver by low doses of gamma-rays. Biochim Biophys Acta. 1998; 1381(3):312-8. DOI: 10.1016/s0304-4165(98)00043-9. View

Koch O, Pani G, Borrello S, Colavitti R, Cravero A, Farre S . Oxidative stress and antioxidant defenses in ethanol-induced cell injury. Mol Aspects Med. 2004; 25(1-2):191-8. DOI: 10.1016/j.mam.2004.02.019. View

Yoshimoto M, Kataoka T, Toyota T, Taguchi T, Yamaoka K . Inhibitory effects of prior low-dose X-irradiation on cold-induced brain injury in mouse. Inflammation. 2011; 35(1):89-97. DOI: 10.1007/s10753-011-9293-9. View

Baehner R, Murrmann S, Davis J, JOHNSTON Jr R . The role of superoxide anion and hydrogen peroxide in phagocytosis-associated oxidative metabolic reactions. J Clin Invest. 1975; 56(3):571-6. PMC: 301904. DOI: 10.1172/JCI108126. View

KOCH O, Galeotti T, Bartoli G, Boveris A . Alcohol-induced oxidative stress in rat liver. Xenobiotica. 1991; 21(8):1077-84. DOI: 10.3109/00498259109039547. View

10.

Strubelt O, Younes M, Pentz R . Enhancement by glutathione depletion of ethanol-induced acute hepatotoxicity in vitro and in vivo. Toxicology. 1987; 45(2):213-23. DOI: 10.1016/0300-483x(87)90107-7. View

11.

Vogt B, Richie Jr J . Glutathione depletion and recovery after acute ethanol administration in the aging mouse. Biochem Pharmacol. 2007; 73(10):1613-21. PMC: 1930162. DOI: 10.1016/j.bcp.2007.01.033. View

12.

Krewski D, Lubin J, Zielinski J, Alavanja M, Catalan V, Field R . Residential radon and risk of lung cancer: a combined analysis of 7 North American case-control studies. Epidemiology. 2005; 16(2):137-45. DOI: 10.1097/01.ede.0000152522.80261.e3. View

13.

Wheeler B, Allen J, Depledge M, Curnow A . Radon and skin cancer in southwest England: an ecologic study. Epidemiology. 2011; 23(1):44-52. DOI: 10.1097/EDE.0b013e31823b6139. View

14.

AEBI H, Wyss S, Scherz B, Gross J . Properties of erythrocyte catalase from homozygotes and heterozygotes for Swiss-type acatalasemia. Biochem Genet. 1976; 14(9-10):791-807. DOI: 10.1007/BF00485342. View

15.

Muller A, Sies H . Role of alcohol dehydrogenase activity and the acetaldehyde in ethanol- induced ethane and pentane production by isolated perfused rat liver. Biochem J. 1982; 206(1):153-6. PMC: 1158561. DOI: 10.1042/bj2060153. View

16.

Bradford M . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-54. DOI: 10.1016/0003-2697(76)90527-3. View

17.

Dey A, Cederbaum A . Alcohol and oxidative liver injury. Hepatology. 2006; 43(2 Suppl 1):S63-74. DOI: 10.1002/hep.20957. View

18.

Kataoka T, Teraoka J, Sakoda A, Nishiyama Y, Yamato K, Monden M . Protective effects of radon inhalation on carrageenan-induced inflammatory paw edema in mice. Inflammation. 2011; 35(2):713-22. DOI: 10.1007/s10753-011-9364-y. View

19.

Yamaoka K, Mitsunobu F, Hanamoto K, Shibuya K, Mori S, Tanizaki Y . Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy. J Radiat Res. 2004; 45(1):83-8. DOI: 10.1269/jrr.45.83. View

20.

Denman A, Eatough J, Gillmore G, Phillips P . Assessment of health risks to skin and lung of elevated radon levels in abandoned mines. Health Phys. 2003; 85(6):733-9. DOI: 10.1097/00004032-200312000-00018. View