Radiotherapy Versus Stenting in Treating Malignant Dysphagia

Overview

Journal J Gastrointest Oncol

Date 2012 Dec 4

PMID 23205308

Citations 7

Authors

Hany Eldeeb

Hend Ahmed El-Hadaad

Affiliations

Soon will be listed here.

Abstract

The most commonly used treatments for maliganat dysphagia are stenting and radiotherapy (RT). A prospective data of 91 patients with locally advanced or metastatic esophageal cancer who has been treated with either palliative RT, stent or both. Group I had RT only, Group II had stent only and group III had both RT and stent. The median overall survival was 169, 119 and 237 in the three groups respectively. The difference between GI & III was statistically significant (P=0.01). Combinations of stent and RT may provide survival benefit in patients with malignant dysphagia. A randomized clinical trial is recommended.

Citing Articles

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References

Song H, Lee D, Seo T, Kim S, Jung H, Kim J . Retrievable covered nitinol stents: experiences in 108 patients with malignant esophageal strictures. J Vasc Interv Radiol. 2002; 13(3):285-93. DOI: 10.1016/s1051-0443(07)61722-9. View

Conio M, Repici A, Battaglia G, De Pretis G, Ghezzo L, Bittinger M . A randomized prospective comparison of self-expandable plastic stents and partially covered self-expandable metal stents in the palliation of malignant esophageal dysphagia. Am J Gastroenterol. 2007; 102(12):2667-77. DOI: 10.1111/j.1572-0241.2007.01565.x. View

Siersema P . Esophageal cancer. Gastroenterol Clin North Am. 2008; 37(4):943-64, x. DOI: 10.1016/j.gtc.2008.09.012. View

Allum W, Griffin S, Watson A, Colin-Jones D . Guidelines for the management of oesophageal and gastric cancer. Gut. 2002; 50 Suppl 5:v1-23. PMC: 1867706. DOI: 10.1136/gut.50.90005.v1. View

Homs M, Steyerberg E, Eijkenboom W, Tilanus H, Stalpers L, Bartelsman J . Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial. Lancet. 2004; 364(9444):1497-504. DOI: 10.1016/S0140-6736(04)17272-3. View

Langer F, Schoppmann S, Prager G, Tomaselli F, Pluschnig U, Hejna M . Temporary placement of self-expanding oesophageal stents as bridging for neo-adjuvant therapy. Ann Surg Oncol. 2009; 17(2):470-5. DOI: 10.1245/s10434-009-0760-6. View

Yu Y, Yang G, Liu Y, Shen B . Clinical evaluation of radiotherapy for advanced esophageal cancer after metallic stent placement. World J Gastroenterol. 2004; 10(14):2145-6. PMC: 4572354. DOI: 10.3748/wjg.v10.i14.2145. View

Bown S . Palliation of malignant dysphagia: surgery, radiotherapy, laser, intubation alone or in combination?. Gut. 1991; 32(8):841-4. PMC: 1378948. DOI: 10.1136/gut.32.8.841. View

Falk J, Carstens H, Lundell L, Albertsson M . Incidence of carcinoma of the oesophagus and gastric cardia. Changes over time and geographical differences. Acta Oncol. 2007; 46(8):1070-4. DOI: 10.1080/02841860701403046. View

10.

ODonnell C, Fullarton G, Watt E, Lennon K, Murray G, Moss J . Randomized clinical trial comparing self-expanding metallic stents with plastic endoprostheses in the palliation of oesophageal cancer. Br J Surg. 2002; 89(8):985-92. DOI: 10.1046/j.1365-2168.2002.02152.x. View

11.

Karim-Kos H, de Vries E, Soerjomataram I, Lemmens V, Siesling S, Coebergh J . Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. Eur J Cancer. 2008; 44(10):1345-89. DOI: 10.1016/j.ejca.2007.12.015. View

12.

Zhong J, Wu Y, Xu Z, Liu X, Xu B, Zhai Z . Treatment of medium and late stage esophageal carcinoma with combined endoscopic metal stenting and radiotherapy. Chin Med J (Engl). 2003; 116(1):24-8. View

13.

Watt E, Whyte F . The experience of dysphagia and its effect on the quality of life of patients with oesophageal cancer. Eur J Cancer Care (Engl). 2003; 12(2):183-93. DOI: 10.1046/j.1365-2354.2003.00376.x. View

14.

Steevens J, Botterweck A, Dirx M, van den Brandt P, Schouten L . Trends in incidence of oesophageal and stomach cancer subtypes in Europe. Eur J Gastroenterol Hepatol. 2009; 22(6):669-78. DOI: 10.1097/MEG.0b013e32832ca091. View

15.

Weigel T, Frumiento C, Gaumintz E . Endoluminal palliation for dysphagia secondary to esophageal carcinoma. Surg Clin North Am. 2002; 82(4):747-61. DOI: 10.1016/s0039-6109(02)00037-3. View

16.

OGILVIE A, Dronfield M, Ferguson R, Atkinson M . Palliative intubation of oesophagogastric neoplasms at fibreoptic endoscopy. Gut. 1982; 23(12):1060-7. PMC: 1419858. DOI: 10.1136/gut.23.12.1060. View

17.

Slabber C, Nel J, Schoeman L, Burger W, FALKSON G, Falkson C . A randomized study of radiotherapy alone versus radiotherapy plus 5-fluorouracil and platinum in patients with inoperable, locally advanced squamous cancer of the esophagus. Am J Clin Oncol. 1998; 21(5):462-5. DOI: 10.1097/00000421-199810000-00008. View

18.

Hirdes M, Vleggaar F, Siersema P . Stent placement for esophageal strictures: an update. Expert Rev Med Devices. 2011; 8(6):733-55. DOI: 10.1586/erd.11.44. View

19.

Han Y, Peng L, Fang Q, Li Q . [Value of radiotherapy and chemotherapy after SEMS implantation operation in patients with malignant esophageal stricture]. Ai Zheng. 2004; 23(6):682-4. View