Time Space Translation: a Hox Mechanism for Vertebrate A-p Patterning

Overview

Journal Curr Genomics

Publisher Bentham Science Publishers

Date 2012 Dec 4

PMID 23204919

Citations 12

Authors

Aj Durston

S Wacker

N Bardine

Hj Jansen

Affiliations

Soon will be listed here.

Abstract

The vertebrate A-P axis is a time axis. The head is made first and more and more posterior levels are made at later and later stages. This is different to the situation in most other animals, for example, in Drosophila. Central to this timing is Hox temporal collinearity (see below). This occurs rarely in the animal kingdom but is characteristic of vertebrates and is used to generate the primary axial Hox pattern using time space translation and to integrate successive derived patterns (see below). This is thus a different situation than in Drosophila, where the primary pattern guiding Hox spatial collinearity is generated externally, by the gap and segmentation genes.

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