The Dynamic Lives of T Cells: New Approaches and Themes

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2012 Dec 4

PMID 23200626

Citations 9

Authors

Yvonne J Yamanaka

Todd M Gierahn

J Christopher Love

Affiliations

Soon will be listed here.

Abstract

Activated T cells have classically been thought to progress unidirectionally through discrete phenotypic states and differentiate into static lineages. It is increasingly evident, however, that T cells exhibit much more complex and flexible dynamic behaviors than initially appreciated, and that these behaviors influence the efficacy of T cell responses to immunological challenges. In this review, we discuss how new technologies for monitoring the dynamics of T cells are enhancing the resolution of the fine phenotypic and functional heterogeneity within populations of T cells and revealing how individual T cells transition among a continuum of states. Such insights into the dynamic properties of T cells should improve immune monitoring and inform strategies for therapeutic interventions.

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