Biogenesis of Mammalian MicroRNAs: a Global View

Overview

Journal Genomics Proteomics Bioinformatics

Specialty Biology

Date 2012 Dec 4

PMID 23200133

Citations 65

Authors

Paul Graves

Yan Zeng

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are approximately 22-nucleotide-long non-coding RNAs that are important regulators of gene expression in eukaryotes. miRNAs are first transcribed as long primary transcripts, which then undergo a series of processing steps to produce the single-stranded mature miRNAs. This article reviews our current knowledge of the mechanism and regulation of mammalian miRNA expression and points out areas of research that may enhance our understanding of how the specificity and efficiency of miRNA production is controlled in vivo.

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