Early Life Socioeconomic Factors and Genomic DNA Methylation in Mid-life

Overview

Journal Epigenetics

Specialty Genetics

Date 2012 Dec 1

PMID 23196856

Citations 41

Authors

Parisa Tehranifar

Hui-Chen Wu

Xiaozhou Fan

Julie D Flom

Jennifer S Ferris

Yoon Hee Cho

Karina Gonzalez

Regina M Santella

Mary Beth Terry

Affiliations

Soon will be listed here.

Abstract

Epigenetic modifications may be one mechanism linking early life factors, including parental socioeconomic status (SES), to adult onset disease risk. However, SES influences on DNA methylation patterns remain largely unknown. In a US birth cohort of women, we examined whether indicators of early life and adult SES were associated with white blood cell methylation of repetitive elements (Sat2, Alu and LINE-1) in adulthood. Low family income at birth was associated with higher Sat2 methylation (β = 19.7, 95% CI: 0.4, 39.0 for lowest vs. highest income quartile) and single parent family was associated with higher Alu methylation (β = 23.5, 95% CI: 2.6, 44.4), after adjusting for other early life factors. Lower adult education was associated with lower Sat2 methylation (β = -16.7, 95% CI: -29.0, -4.5). There were no associations between early life SES and LINE-1 methylation. Overall, our preliminary results suggest possible influences of SES across the life-course on genomic DNA methylation in adult women. However, these preliminary associations need to be replicated in larger prospective studies.

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