Inhibitory Effect of Heliantriol C; a Component of Edible Chrysanthemum, on Tumor Promotion by 12-O-tetradecanoylphorbol-13-acetate in Two-stage Carcinogenesis in Mouse Skin

Overview

Journal Phytomedicine

Specialty Rehabilitation Medicine

Date 2012 Dec 1

PMID 23195844

Citations 4

Authors

K Yasukawa

T Akihisa

Y Kasahara

M Ukiya

K Kumaki

T Tamura

S Yamanouchi

M Takido

Affiliations

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Abstract

Two hydroxy taraxastane-type triterpenes, faradiol and heliantriol C, have been isolated from the ligulate flowers of Chrysanthemum morifolium Ramat. var. sinense Makino fa. esculentum Makino, the edible Chrysanthemum. These compounds showed strong inhibitory activity against 12-O-tetradecanoyl-phorbol-13-aetate (TPA)-induced inflammation in mice. At 0.2 μmol/mouse, these compounds markedly inhibited the promoting effect of TPA (1 μg/mouse) on skin tumor formation followed by 7,12-dimethylbenz[a]anthracene (50 μg/mouse).

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