Inhibitory Effects of the Lichen Metabolite Lobaric Acid on Arachidonate Metabolism in Vitro

Overview

Journal Phytomedicine

Specialty Rehabilitation Medicine

Date 2012 Dec 1

PMID 23194623

Citations 4

Authors

K Ingolfsdottir

S R Gissurarson

B Muller-Jakic

W Breu

H Wagner

Affiliations

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Abstract

An extract containing phenolic constituents of the lichen Stereocaulon alpinum was shown to exhibit potent in vitro inhibitory effects on arachidonate 5-lipoxygenase from porcine leucocytes. The active component has been identified as the orcinol depsidone lobaric acid (1), which shows dose-dependent inhibitory effects on the enzyme, with an IC(50) value of 7.3 μM. Lobaric acid exhibits approximately 4-fold in vitro selectivity for 5-lipoxygenase as compared to cyclooxygenase.

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