Synergic Effect of Photodynamic Therapy with Methylene Blue and Surfactants in the Inhibition of Candida Albicans

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 2012 Nov 29

PMID 23187768

Citations 7

Authors

Juliana Pereira Lyon

Rafael Reis Rezende

Mariana Penido Rabelo

Carlos Jose de Lima

Leonardo Marmo Moreira

Affiliations

Soon will be listed here.

Abstract

Photodynamic therapy (PDT) has been originally developed for the treatment of cancer, but it has been successfully employed in the treatment of infectious diseases, including fungal infections. Surfactants are amphiphilic compounds that also have antifungal properties. The present work demonstrates the synergic effect of PDT with methylene blue (MB) and LED combined with four different surfactants in the killing of Candida albicans. Subinhibitory concentrations of CTAC, HPS, SDS and Triton X-100 were tested with MB PDT. The combined therapies proved to be more efficient than PDT or surfactants separately. The best results were obtained with CTAC and HPS and PDT with MB at the concentration of 32 μg/mL. In conclusion, the combination of surfactants and PDT is an alternative antifungal treatment that can achieve more effective performance with minimal discomfort to the patient.

Citing Articles

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Amphiphilic di-cationic methylene blue for improving antibacterial photodynamic efficiency through high accumulation and low aggregation on bacterial cell surfaces.

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Photosensitizers Mediated Photodynamic Inactivation against Fungi.

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Photodynamic therapy combined with antifungal drugs against chromoblastomycosis and the effect of ALA-PDT on Fonsecaea in vitro.

Hu Y, Qi X, Sun H, Lu Y, Hu Y, Chen X PLoS Negl Trop Dis. 2019; 13(10):e0007849.

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Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells.

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