Multidisciplinary Management of Locally Advanced-borderline Resectable Adenocarcinoma of the Head of the Pancreas

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2012 Nov 27

PMID 23180346

Citations 4

Authors

F Calvo

C Guillen Ponce

M Munoz Beltran

A Sanjuanbenito Dehesa

Affiliations

Soon will be listed here.

Abstract

Borderline resectable pancreatic head carcinoma is a challenging disease that requires multidisciplinary approach to obtain maximal benefits from current therapeutical possibilities. We review current knowledge and therapeutic options for the patients from the surgical, medical oncology and radiotherapy views and emphasize the need for a coordinated multidisciplinary approach to obtain optimal results.

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References

Wilkowski R, Thoma M, Duhmke E, Rau H, Heinemann V . Concurrent chemoradiotherapy with gemcitabine and cisplatin after incomplete (R1) resection of locally advanced pancreatic carcinoma. Int J Radiat Oncol Biol Phys. 2004; 58(3):768-72. DOI: 10.1016/j.ijrobp.2003.07.002. View

. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Gastrointestinal Tumor Study Group. Cancer. 1987; 59(12):2006-10. DOI: 10.1002/1097-0142(19870615)59:12<2006::aid-cncr2820591206>3.0.co;2-b. View

Li H, Zeng M, Zhou K, Jin D, Lou W . Pancreatic adenocarcinoma: the different CT criteria for peripancreatic major arterial and venous invasion. J Comput Assist Tomogr. 2005; 29(2):170-5. DOI: 10.1097/01.rct.0000155060.73107.83. View

Chang K . State of the art lecture: endoscopic ultrasound (EUS) and FNA in pancreatico-biliary tumors. Endoscopy. 2006; 38 Suppl 1:S56-60. DOI: 10.1055/s-2006-946654. View

White R, Xie H, Gottfried M, Czito B, Hurwitz H, Morse M . Significance of histological response to preoperative chemoradiotherapy for pancreatic cancer. Ann Surg Oncol. 2005; 12(3):214-21. DOI: 10.1245/ASO.2005.03.105. View

Brunner T, Grabenbauer G, Meyer T, Golcher H, Sauer R, Hohenberger W . Primary resection versus neoadjuvant chemoradiation followed by resection for locally resectable or potentially resectable pancreatic carcinoma without distant metastasis. A multi-centre prospectively randomised phase II-study of the.... BMC Cancer. 2007; 7:41. PMC: 1821337. DOI: 10.1186/1471-2407-7-41. View

Yeo C, Abrams R, Grochow L, Sohn T, Ord S, Hruban R . Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg. 1997; 225(5):621-33; discussion 633-6. PMC: 1190807. DOI: 10.1097/00000658-199705000-00018. View

Greer S, Pipas J, Sutton J, Zaki B, Tsapakos M, Colacchio T . Effect of neoadjuvant therapy on local recurrence after resection of pancreatic adenocarcinoma. J Am Coll Surg. 2008; 206(3):451-7. DOI: 10.1016/j.jamcollsurg.2007.10.002. View

Regine W, Winter K, Abrams R, Safran H, Hoffman J, Konski A . Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U.S. Intergroup/RTOG 9704 phase III trial. Ann Surg Oncol. 2011; 18(5):1319-26. PMC: 3548408. DOI: 10.1245/s10434-011-1630-6. View

10.

Martin 2nd R, Scoggins C, Egnatashvili V, Staley C, McMasters K, Kooby D . Arterial and venous resection for pancreatic adenocarcinoma: operative and long-term outcomes. Arch Surg. 2009; 144(2):154-9. DOI: 10.1001/archsurg.2008.547. View

11.

Ahmed S, Bochkarev V, Oleynikov D, Sasson A . Patients with pancreatic adenocarcinoma benefit from staging laparoscopy. J Laparoendosc Adv Surg Tech A. 2006; 16(5):458-63. DOI: 10.1089/lap.2006.16.458. View

12.

Warshaw A, Gu Z, Wittenberg J, Waltman A . Preoperative staging and assessment of resectability of pancreatic cancer. Arch Surg. 1990; 125(2):230-3. DOI: 10.1001/archsurg.1990.01410140108018. View

13.

Von Hoff D, Ramanathan R, Borad M, Laheru D, Smith L, Wood T . Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol. 2011; 29(34):4548-54. PMC: 3565012. DOI: 10.1200/JCO.2011.36.5742. View

14.

Rocha Lima C, Green M, Rotche R, Miller Jr W, Jeffrey G, Cisar L . Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol. 2004; 22(18):3776-83. DOI: 10.1200/JCO.2004.12.082. View

15.

Calvo F, Valentini V . Radiotherapy for pancreatic cancer: systematic nihilism or intraoperative realism. Radiother Oncol. 2008; 87(3):314-7. DOI: 10.1016/j.radonc.2008.03.022. View

16.

Breslin T, Hess K, Harbison D, Jean M, Cleary K, Dackiw A . Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: treatment variables and survival duration. Ann Surg Oncol. 2001; 8(2):123-32. DOI: 10.1007/s10434-001-0123-4. View

17.

Ishii H, Furuse J, Boku N, Okusaka T, Ikeda M, Ohkawa S . Phase II study of gemcitabine chemotherapy alone for locally advanced pancreatic carcinoma: JCOG0506. Jpn J Clin Oncol. 2010; 40(6):573-9. DOI: 10.1093/jjco/hyq011. View

18.

Micames C, Jowell P, White R, Paulson E, Nelson R, Morse M . Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA. Gastrointest Endosc. 2003; 58(5):690-5. DOI: 10.1016/s0016-5107(03)02009-1. View

19.

White R, Winston C, Gonen M, DAngelica M, Jarnagin W, Fong Y . Current utility of staging laparoscopy for pancreatic and peripancreatic neoplasms. J Am Coll Surg. 2008; 206(3):445-50. DOI: 10.1016/j.jamcollsurg.2007.09.021. View

20.

Kalser M, Ellenberg S . Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg. 1985; 120(8):899-903. DOI: 10.1001/archsurg.1985.01390320023003. View