Ag Nanorod Based Surface-enhanced Raman Spectroscopy Applied to Bioanalytical Sensing
Overview
Authors
Affiliations
Recent progress in substrate nanofabrication has led to the development of Ag nanorod arrays as uniform, reproducible, large area SERS-active substrates with high signal enhancement. These novel nanostructures fabricated by oblique angle vapor deposition (OAD) offer a robust platform for the rapid detection of biological agents and open new perspectives for the development and integration of biomedical diagnostic for clinical and therapeutic applications. Ag nanorod arrays have been investigated as SERS-active substrates for the detection and identification of pathogens, including bacteria and viruses, as well as to evaluate the potential of this biosensing platform for bio-recognition of high affinity events using oligonucleotide-modified substrates. This review summarizes the various nanostructured substrates designed for SERS-based applications, highlights the nanofabrication methodology used to produce Ag nanorod arrays, outlines their morphological and physical properties, and provides a summary of the most recent uses of these substrates for clinical diagnostic and biomedical applications.
Zou S, Ma L, Li J, Liu Y, Zhao D, Zhang Z Front Chem. 2019; 7:376.
PMID: 31214564 PMC: 6558050. DOI: 10.3389/fchem.2019.00376.
Highly sensitive detection of influenza virus with SERS aptasensor.
Kukushkin V, Ivanov N, Novoseltseva A, Gambaryan A, Yaminsky I, Kopylov A PLoS One. 2019; 14(4):e0216247.
PMID: 31022287 PMC: 6483365. DOI: 10.1371/journal.pone.0216247.
Okeil S, Schneider J Beilstein J Nanotechnol. 2018; 9:2813-2831.
PMID: 30498654 PMC: 6244324. DOI: 10.3762/bjnano.9.263.
Subr M, Petr M, Kylian O, Stepanek J, Veis M, Prochazka M Sci Rep. 2017; 7(1):4293.
PMID: 28655920 PMC: 5487367. DOI: 10.1038/s41598-017-04565-0.
Convertino A, Mussi V, Maiolo L Sci Rep. 2016; 6:25099.
PMID: 27112197 PMC: 4844982. DOI: 10.1038/srep25099.