Differential Requirements for HIV-1 Vif-mediated APOBEC3G Degradation and RUNX1-mediated Transcription by Core Binding Factor Beta

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2012 Nov 24

PMID 23175372

Citations 24

Authors

Juan Du

Ke Zhao

Yajuan Rui

Peng Li

Xiaohong Zhou

Wenyan Zhang

Xiao-Fang Yu

Affiliations

Soon will be listed here.

Abstract

Core binding factor beta (CBFβ), a transcription regulator through RUNX binding, was recently reported critical for Vif function. Here, we mapped the primary functional domain important for Vif function to amino acids 15 to 126 of CBFβ. We also revealed that different lengths and regions are required for CBFβ to assist Vif or RUNX. The important interaction domains that are uniquely required for Vif but not RUNX function represent novel targets for the development of HIV inhibitors.

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