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Tumor-infiltrating B Cells: The Ignored Players in Tumor Immunology

Overview
Journal Oncoimmunology
Specialty Allergy & Immunology
Date 2012 Nov 22
PMID 23170274
Citations 39
Authors
Michael Linnebacher
Claudia Maletzki
Affiliations
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Abstract

B cells infiltrating into solid tumors are poorly investigated despite their described positive prognostic value. Whether this antitumor potential comes from either the antigen presentation or the antibody production capacity of B cells, or both, is unknown. Our recently published method on tumor-infiltrating B lymphocyte cloning may prove helpful in unraveling the actual relevance of these cells for tumor development and response to therapy.

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