The Risk of Cellulitis in Cirrhotic Patients: a Nationwide Population-based Study in Taiwan

Overview

Journal Gut Liver

Specialty Gastroenterology

Date 2012 Nov 22

PMID 23170154

Citations 9

Authors

Ming-Nan Lin

Chen-Chi Tsai

Tsung-Hsing Hung

Chih-Chun Tsai

Affiliations

Soon will be listed here.

Abstract

Background/aims: Cellulitis is a common infectious disease. However, the risk of cellulitis in cirrhotic patients is not well established, and whether liver cirrhosis is a risk factor for cellulitis remains unknown. This study evaluated the relationship between cellulitis and liver cirrhosis.

Methods: The National Health Insurance Database, which was derived from the Taiwan National Health Insurance program, was used to identify patients. The study group consisted of 39,966 patients with liver cirrhosis, and the comparison group consisted of 39,701 randomly selected age- and sex-matched patients.

Results: During the 3-year follow-up period, 2,674 (6.7%) patients with liver cirrhosis developed cellulitis, and 1,587 (4.0%) patients without liver cirrhosis developed cellulitis (p<0.001). Following a Cox's regression analysis adjusted for age, sex, and underlying medical disorders, the cirrhotic patients demonstrated a greater risk for the occurrence of cellulitis than the non-cirrhotic patients during the 3-year period (hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.55 to 1.77; p<0.001). Additionally, cirrhotic patients with complications also had a greater risk for the occurrence of cellulitis than those patients without complications (HR, 1.23; 95% CI, 1.14 to 1.33; p<0.001).

Conclusions: We conclude that cirrhotic patients have a greater risk of cellulitis than non-cirrhotic patients.

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