Spontaneous Reperfusion After in Situ Thromboembolic Stroke in Mice

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Nov 21

PMID 23166825

Citations 6

Authors

Anne Durand

Fabien Chauveau

Tae-Hee Cho

Radu Bolbos

Jean-Baptiste Langlois

Laure Hermitte

Marlene Wiart

Yves Berthezene

Norbert Nighoghossian

Affiliations

Soon will be listed here.

Abstract

Injection of thrombin into the middle cerebral artery (MCA) of mice has been proposed as a new model of thromboembolic stroke. The present study used sequential multiparametric Magnetic Resonance Imaging (MRI), including Magnetic Resonance Angiography (MRA), Diffusion-Weighted Imaging (DWI) and Perfusion-Weighted Imaging (PWI), to document MCA occlusion, PWI-DWI mismatch, and lesion development. In the first experiment, complete MCA occlusion and reproducible hypoperfusion were obtained in 85% of animals during the first hour after stroke onset. In the second experiment, 80% of animals showed partial to complete reperfusion during a three-hour follow-up. Spontaneous reperfusion thus contributed to the variability in ischemic volume in this model. The study confirmed the value of the model for evaluating new thrombolytic treatments, but calls for extended MRI follow-up at the acute stage in therapeutic studies.

Citing Articles

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