Identification of Genetic Suppressors of the Sin3A Knockdown Wing Phenotype

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Nov 21

PMID 23166712

Citations 6

Authors

Aishwarya Swaminathan

Valerie L Barnes

Stephanie Fox

Sarah Gammouh

Lori A Pile

Affiliations

Soon will be listed here.

Abstract

The role of the Sin3A transcriptional corepressor in regulating the cell cycle is established in various metazoans. Little is known, however, about the signaling pathways that trigger or are triggered by Sin3A function. To discover genes that work in similar or opposing pathways to Sin3A during development, we have performed an unbiased screen of deficiencies of the Drosophila third chromosome. Additionally, we have performed a targeted loss of function screen to identify cell cycle genes that genetically interact with Sin3A. We have identified genes that encode proteins involved in regulation of gene expression, signaling pathways and cell cycle that can suppress the curved wing phenotype caused by the knockdown of Sin3A. These data indicate that Sin3A function is quite diverse and impacts a wide variety of cellular processes.

Citing Articles

Systematic Analysis of SIN3 Histone Modifying Complex Components During Development.

Barnes V, Laity K, Pilecki M, Pile L Sci Rep. 2018; 8(1):17048.

PMID: 30451916 PMC: 6242963. DOI: 10.1038/s41598-018-35093-0.

Suppression of Sin3A activity promotes differentiation of pluripotent cells into functional neurons.

Halder D, Lee C, Hyun J, Chang G, Cheong E, Shin I Sci Rep. 2017; 7:44818.

PMID: 28303954 PMC: 5356016. DOI: 10.1038/srep44818.

The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism.

Liu M, Pile L J Biol Chem. 2016; 292(5):1970-1976.

PMID: 28028175 PMC: 5290966. DOI: 10.1074/jbc.M116.749754.

The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3.

Gajan A, Barnes V, Liu M, Saha N, Pile L Epigenetics Chromatin. 2016; 9:4.

PMID: 26848313 PMC: 4740996. DOI: 10.1186/s13072-016-0053-9.

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability.

Liu M, Barnes V, Pile L G3 (Bethesda). 2015; 6(1):121-32.

PMID: 26546310 PMC: 4704710. DOI: 10.1534/g3.115.024273.

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