Healthcare Professional Surveys to Investigate the Implementation of the Isotretinoin Pregnancy Prevention Programme: a Descriptive Study
Overview
Authors
Affiliations
Objective: Three online surveys explored compliance with the PPP by pharmacists and dermatologists, in the Netherlands. In 2007 and 2011, two pharmacist surveys were conducted to assess improvement over time.
Methods: In 2007, survey was sent to members of the Utrecht Pharmacy Panel for Education & Research (UPPER) network (n = 1000) and in 2011, to the research group of the Dutch Association of Pharmacists (KNMP) (n = 556). In 2010, a survey was sent to 564 dermatologists of the Dutch Association of Dermatology and Venereology (NVDV).
Results: Both pharmacists' questionnaires had response rates of 20% and the dermatologist questionnaire of 28%. Pharmacists' checks on 30-day dispensing remained 82%, but a check whether the prescription is out-of-date decreased (61 to 53%). Pharmacists asked the patient for a negative pregnancy test in 15%, but use of contraception was checked by 44 - 49%. One hundred and five dermatologists (64%) always prescribe contraception; 35 (22%) occasionally. Ninety-three percent of the dermatologists were of the opinion that they performed the PPP. Analysis of different elements of the PPP showed that 41 (25%) were compliant.
Conclusions: The observed non-adherence to the isotretinoin PPP calls for careful evaluation of risk minimisation plans and participation of all stakeholders in the development of these plans.
Jarab A, Al-Azzam S, Al-Mutairi S, Abu Heshmeh S, Mukattash T, Al-Qerem W Heliyon. 2023; 9(11):e22354.
PMID: 38053915 PMC: 10694323. DOI: 10.1016/j.heliyon.2023.e22354.
Duran C, Riera-Arnau J, Abtahi S, Pajouheshnia R, Hoxhaj V, Gamba M Front Pharmacol. 2023; 14:1207976.
PMID: 37663263 PMC: 10469888. DOI: 10.3389/fphar.2023.1207976.
Isotretinoin; A review on the Utilization Pattern in Pregnancy.
Khiali S, Gharekhani A, Entezari-Maleki T Adv Pharm Bull. 2018; 8(3):377-382.
PMID: 30276133 PMC: 6156490. DOI: 10.15171/apb.2018.044.
Medications and pregnancy: The role of community pharmacists - A descriptive study.
Leung H, Saini B, Ritchie H PLoS One. 2018; 13(5):e0195101.
PMID: 29742159 PMC: 5942805. DOI: 10.1371/journal.pone.0195101.
Goedecke T, Morales D, Pacurariu A, Kurz X Br J Clin Pharmacol. 2017; 84(3):419-433.
PMID: 29105853 PMC: 5809349. DOI: 10.1111/bcp.13469.