Hair Follicle: a Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine

Overview

Journal Tissue Eng Part B Rev

Specialties Anatomy & Histology
Biotechnology

Date 2012 Nov 20

PMID 23157470

Citations 33

Authors

Panagiotis Mistriotis

Stelios T Andreadis

Affiliations

Soon will be listed here.

Abstract

The adult body harbors powerful reservoirs of stem cells that enable tissue regeneration under homeostatic conditions or in response to disease or injury. The hair follicle (HF) is a readily accessible mini organ within the skin and contains stem cells from diverse developmental origins that were shown to have surprisingly broad differentiation potential. In this review, we discuss the biology of the HF with particular emphasis on the various stem cell populations residing within the tissue. We summarize the existing knowledge on putative HF stem cell markers, the differentiation potential, and technologies to isolate and expand distinct stem cell populations. We also discuss the potential of HF stem cells for drug and gene delivery, tissue engineering, and regenerative medicine. We propose that the abundance of stem cells with broad differentiation potential and the ease of accessibility makes the HF an ideal source of stem cells for gene and cell therapies.

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