Inflammation and Diabetes-accelerated Atherosclerosis: Myeloid Cell Mediators

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2012 Nov 17

PMID 23153419

Citations 34

Authors

Jenny E Kanter

Karin E Bornfeldt

Affiliations

Soon will be listed here.

Abstract

Monocytes and macrophages respond to and govern inflammation by producing a plethora of inflammatory modulators, including cytokines, chemokines, and arachidonic acid (C20:4)-derived lipid mediators. One of the most prevalent inflammatory diseases is cardiovascular disease, caused by atherosclerosis, and accelerated by diabetes. Recent research has demonstrated that monocytes/macrophages from diabetic mice and humans with type 1 diabetes show upregulation of the enzyme, acyl-CoA synthetase 1 (ACSL1), which promotes C20:4 metabolism, and that ACSL1 inhibition selectively protects these cells from the inflammatory and proatherosclerotic effects of diabetes, in mice. Increased understanding of the role of ACSL1 and other culprits in monocytes/macrophages in inflammation and diabetes-accelerated atherosclerosis offers hope for new treatment strategies to combat diabetic vascular disease.

Citing Articles

Common ground on immune infiltration landscape and diagnostic biomarkers in diabetes-complicated atherosclerosis: an integrated bioinformatics analysis.

Qi Y, Zhang Y, Guan S, Liu L, Wang H, Chen Y Front Endocrinol (Lausanne). 2024; 15:1381229.

PMID: 39145311 PMC: 11323117. DOI: 10.3389/fendo.2024.1381229.

Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study.

Moller A, Vasan R, Levy D, Andersson C, Lin H Sci Rep. 2023; 13(1):21581.

PMID: 38062110 PMC: 10703905. DOI: 10.1038/s41598-023-48848-1.

Dynamics of Docosahexaenoic Acid Utilization by Mouse Peritoneal Macrophages.

Monge P, Astudillo A, Pereira L, Balboa M, Balsinde J Biomolecules. 2023; 13(11).

PMID: 38002317 PMC: 10669016. DOI: 10.3390/biom13111635.

Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis.

Wang L, Mao Z, Shao F IET Syst Biol. 2023; 17(6):327-335.

PMID: 37823415 PMC: 10725708. DOI: 10.1049/syb2.12079.

"Arterial stiffness is not associated with changes in the circadian pattern of blood pressure in patients with type 1 diabetes mellitus and cardiovascular autonomic dysfunction".

Nattero-Chavez L, Bayona Cebada A, Fernandez-Duran E, Quintero Tobar A, Dorado Avendano B, Escobar-Morreale H Diab Vasc Dis Res. 2023; 20(3):14791641231173621.

PMID: 37184151 PMC: 10192811. DOI: 10.1177/14791641231173621.

References

Plump A, Smith J, Hayek T, Aalto-Setala K, Walsh A, Verstuyft J . Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992; 71(2):343-53. DOI: 10.1016/0092-8674(92)90362-g. View

Kazemi M, McDonald C, Shigenaga J, Grunfeld C, Feingold K . Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists. Arterioscler Thromb Vasc Biol. 2005; 25(6):1220-4. DOI: 10.1161/01.ATV.0000159163.52632.1b. View

Johnson C, Lemaitre R, Fahrenbruch C, Hesselson S, Sotoodehnia N, McKnight B . Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Circ Cardiovasc Genet. 2012; 5(4):422-9. PMC: 3422654. DOI: 10.1161/CIRCGENETICS.111.961912. View

Kanter J, Kramer F, Barnhart S, Averill M, Vivekanandan-Giri A, Vickery T . Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A. 2012; 109(12):E715-24. PMC: 3311324. DOI: 10.1073/pnas.1111600109. View

Martin G, Schoonjans K, Lefebvre A, Staels B, Auwerx J . Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem. 1997; 272(45):28210-7. DOI: 10.1074/jbc.272.45.28210. View

Moore K, Tabas I . Macrophages in the pathogenesis of atherosclerosis. Cell. 2011; 145(3):341-55. PMC: 3111065. DOI: 10.1016/j.cell.2011.04.005. View

Bradshaw E, Raddassi K, Elyaman W, Orban T, Gottlieb P, Kent S . Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009; 183(7):4432-9. PMC: 2770506. DOI: 10.4049/jimmunol.0900576. View

Buczynski M, Dumlao D, Dennis E . Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res. 2009; 50(6):1015-38. PMC: 2681385. DOI: 10.1194/jlr.R900004-JLR200. View

Golej D, Askari B, Kramer F, Barnhart S, Vivekanandan-Giri A, Pennathur S . Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells. J Lipid Res. 2011; 52(4):782-93. PMC: 3053208. DOI: 10.1194/jlr.M013292. View

10.

Zhou Y, Wang J, Li L, Yang H, Wen D, He Q . Expanding expression of the 5-lipoxygenase/leukotriene B4 pathway in atherosclerotic lesions of diabetic patients promotes plaque instability. Biochem Biophys Res Commun. 2007; 363(1):30-6. DOI: 10.1016/j.bbrc.2007.08.134. View

11.

Bornfeldt K, Tabas I . Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 2011; 14(5):575-85. PMC: 3217209. DOI: 10.1016/j.cmet.2011.07.015. View

12.

Zaslona Z, Serezani C, Okunishi K, Aronoff D, Peters-Golden M . Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling. Blood. 2012; 119(10):2358-67. PMC: 3311259. DOI: 10.1182/blood-2011-08-374207. View

13.

Furuhashi M, Hotamisligil G . Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov. 2008; 7(6):489-503. PMC: 2821027. DOI: 10.1038/nrd2589. View

14.

Vikramadithyan R, Hu Y, Noh H, Liang C, Hallam K, Tall A . Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. J Clin Invest. 2005; 115(9):2434-43. PMC: 1190371. DOI: 10.1172/JCI24819. View

15.

Zhou C, Pridgen B, King N, Xu J, Breslow J . Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. J Lipid Res. 2011; 52(8):1483-93. PMC: 3137013. DOI: 10.1194/jlr.M014092. View

16.

Agardh H, Folkersen L, Ekstrand J, Marcus D, Swedenborg J, Hedin U . Expression of fatty acid-binding protein 4/aP2 is correlated with plaque instability in carotid atherosclerosis. J Intern Med. 2010; 269(2):200-10. DOI: 10.1111/j.1365-2796.2010.02304.x. View

17.

Renard C, Kramer F, Johansson F, Lamharzi N, Tannock L, von Herrath M . Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Invest. 2004; 114(5):659-68. PMC: 514580. DOI: 10.1172/JCI17867. View

18.

Furuhashi M, Ishimura S, Ota H, Miura T . Lipid chaperones and metabolic inflammation. Int J Inflam. 2011; 2011:642612. PMC: 3206330. DOI: 10.4061/2011/642612. View

19.

Balgoma D, Astudillo A, Perez-Chacon G, Montero O, Balboa M, Balsinde J . Markers of monocyte activation revealed by lipidomic profiling of arachidonic acid-containing phospholipids. J Immunol. 2010; 184(7):3857-65. DOI: 10.4049/jimmunol.0902883. View

20.

Babaev V, Chew J, Ding L, Davis S, Breyer M, Breyer R . Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab. 2008; 8(6):492-501. PMC: 2614698. DOI: 10.1016/j.cmet.2008.09.005. View