No Evidence for Involvement of the Toll-like Receptor (TLR) 4 Gene Asp299Gly and Thr399Ile Polymorphisms in Susceptibility to Primary Gouty Arthritis

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2012 Nov 16

PMID 23152086

Citations 2

Authors

Yu-Feng Qing

Jing-Guo Zhou

Ming Li

Wen-Guang Xie

Cui-Ping Huang

Sheng-ping Zeng

Ling Yin

Affiliations

Soon will be listed here.

Abstract

Previous studies demonstrated that toll-like receptor (TLR) 4 was involved in the development of autoinflammatory disease including gouty arthritis (GA). TLR4 functional gene Asp299Gly and Thr399Ile polymorphisms play a role in some autoinflammatory disease susceptibility. We undertook this study to analyze the association between the genetic polymorphisms within TLR4 gene and the susceptibility to GA in Chinese Han people. Two functional variants, Asp299Gly and Thr399Ile, in the TLR4 gene were genotyped using 5' exonuclease TaqMan technology from 218 male GA patients and 226 ethnically matched controls. None polymorphisms of Asp299Gly and Thr399Ile were detected in all GA cases and controls, which indicates that there is no evidence for involvement of the TLR4 gene Asp299Gly and Thr399Ile polymorphisms in susceptibility to primary GA in the Chinese Han population. Further studies with extended single nucleotide polymorphisms should be performed.

Citing Articles

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References

Miao Z, Li C, Chen Y, Zhao S, Wang Y, Wang Z . Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China. J Rheumatol. 2008; 35(9):1859-64. View

Wallace S, Robinson H, MASI A, Decker J, McCarty D, Yu T . Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum. 1977; 20(3):895-900. DOI: 10.1002/art.1780200320. View

Annemans L, Spaepen E, Gaskin M, Bonnemaire M, Malier V, Gilbert T . Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005. Ann Rheum Dis. 2007; 67(7):960-6. PMC: 2564789. DOI: 10.1136/ard.2007.076232. View

Dalbeth N, Merriman T . Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout. Rheumatology (Oxford). 2008; 48(3):222-6. DOI: 10.1093/rheumatology/ken460. View

Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T . Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med. 2002; 195(1):99-111. PMC: 2196009. DOI: 10.1084/jem.20001858. View

Sheedy F, Marinou I, ONeill L, Wilson A . The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis. Ann Rheum Dis. 2008; 67(9):1328-31. DOI: 10.1136/ard.2007.083337. View

Erridge C, Stewart J, Poxton I . Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J Exp Med. 2003; 197(12):1787-91. PMC: 2193949. DOI: 10.1084/jem.20022078. View

Taniguchi A, Kamatani N . Control of renal uric acid excretion and gout. Curr Opin Rheumatol. 2008; 20(2):192-7. DOI: 10.1097/BOR.0b013e3282f33f87. View

Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M . Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009; 5(6):e1000504. PMC: 2683940. DOI: 10.1371/journal.pgen.1000504. View

10.

Shen X, Shi R, Zhang H, Li K, Zhao Y, Zhang R . The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: a meta-analysis. Digestion. 2010; 81(2):69-77. DOI: 10.1159/000260417. View

11.

Arbour N, Lorenz E, Schutte B, Zabner J, Kline J, Jones M . TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000; 25(2):187-91. DOI: 10.1038/76048. View

12.

Kiechl S, Lorenz E, Reindl M, Wiedermann C, Oberhollenzer F, Bonora E . Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med. 2002; 347(3):185-92. DOI: 10.1056/NEJMoa012673. View

13.

Martinon F, Mayor A, Tschopp J . The inflammasomes: guardians of the body. Annu Rev Immunol. 2009; 27:229-65. DOI: 10.1146/annurev.immunol.021908.132715. View

14.

Shi Y, Evans J, Rock K . Molecular identification of a danger signal that alerts the immune system to dying cells. Nature. 2003; 425(6957):516-21. DOI: 10.1038/nature01991. View

15.

Radstake T, Franke B, Hanssen S, Netea M, Welsing P, Barrera P . The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Arthritis Rheum. 2004; 50(3):999-1001. DOI: 10.1002/art.20114. View

16.

Baker J, Schumacher H . Update on gout and hyperuricemia. Int J Clin Pract. 2009; 64(3):371-7. DOI: 10.1111/j.1742-1241.2009.02188.x. View

17.

Sanchez E, Orozco G, Lopez-Nevot M, Jimenez-Alonso J, Martin J . Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens. 2003; 63(1):54-7. DOI: 10.1111/j.1399-0039.2004.00162.x. View

18.

Ohashi K, Burkart V, Flohe S, Kolb H . Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol. 2000; 164(2):558-61. DOI: 10.4049/jimmunol.164.2.558. View

19.

Yu L, Wang L, Chen S . Endogenous toll-like receptor ligands and their biological significance. J Cell Mol Med. 2010; 14(11):2592-603. PMC: 4373479. DOI: 10.1111/j.1582-4934.2010.01127.x. View

20.

Ghaemi-Oskouie F, Shi Y . The role of uric acid as an endogenous danger signal in immunity and inflammation. Curr Rheumatol Rep. 2011; 13(2):160-6. PMC: 3093438. DOI: 10.1007/s11926-011-0162-1. View