Neuronal Modulation of Airway and Vascular Tone and Their Influence on Nonspecific Airways Responsiveness in Asthma

Overview

Journal J Allergy (Cairo)

Specialty Allergy & Immunology

Date 2012 Nov 15

PMID 23150736

Citations 14

Authors

Brendan J Canning

Ariel Woo

Stuart B Mazzone

Affiliations

Soon will be listed here.

Abstract

The autonomic nervous system provides both cholinergic and noncholinergic neural inputs to end organs within the airways, which includes the airway and vascular smooth muscle. Heightened responsiveness of the airways to bronchoconstrictive agents is a hallmark feature of reactive airways diseases. The mechanisms underpinning airways hyperreactivity still largely remain unresolved. In this paper we summarize the substantial body of evidence that implicates dysfunction of the autonomic nerves that innervate smooth muscle in the airways and associated vasculature as a prominent cause of airways hyperresponsiveness in asthma.

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