Regulation of Genes Involved in Carnitine Homeostasis by PPARα Across Different Species (Rat, Mouse, Pig, Cattle, Chicken, and Human)

Overview

Journal PPAR Res

Publisher Wiley

Date 2012 Nov 15

PMID 23150726

Citations 12

Authors

Robert Ringseis

Gaiping Wen

Klaus Eder

Affiliations

Soon will be listed here.

Abstract

Recent studies in rodents convincingly demonstrated that PPARα is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which cause activation of hepatic PPARα, causes a strong increase of hepatic carnitine concentration in rats. The present paper aimed to comprehensively analyse available data from genetic and animal studies with mice, rats, pigs, cows, and laying hens and from human studies in order to compare the regulation of genes involved in carnitine homeostasis by PPARα across different species. Overall, our comparative analysis indicates that the role of PPARα as a regulator of carnitine homeostasis is well conserved across different species. However, despite demonstrating a well-conserved role of PPARα as a key regulator of carnitine homeostasis in general, our comprehensive analysis shows that this assumption particularly applies to the regulation by PPARα of carnitine uptake which is obviously highly conserved across species, whereas regulation by PPARα of carnitine biosynthesis appears less well conserved across species.

Citing Articles

Intestinal Carnitine Status and Fatty Acid Oxidation in Response to Clofibrate and Medium-Chain Triglyceride Supplementation in Newborn Pigs.

Pike B, Zhao J, Hicks J, Wang F, Hagen R, Liu H Int J Mol Sci. 2023; 24(7).

PMID: 37047049 PMC: 10094207. DOI: 10.3390/ijms24076066.

PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle.

Novakova K, Torok M, Panajatovic M, Bouitbir J, Duong F, Handschin C Int J Mol Sci. 2022; 23(20).

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Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update.

Li N, Zhao H Front Med (Lausanne). 2021; 8:689042.

PMID: 34434943 PMC: 8381051. DOI: 10.3389/fmed.2021.689042.

Transcriptomic alterations induced by aflatoxin B1 and ochratoxin A in LMH cell line.

Choi S, Kim T, Hong M, Park T, Lee H, Lee S Poult Sci. 2020; 99(11):5265-5274.

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Effects of low and high doses of fenofibrate on protein, amino acid, and energy metabolism in rat.

Holecek M, Vodenicarovova M Int J Exp Pathol. 2020; 101(5):171-182.

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