Genome-wide Association Study Heterogeneous Cohort Homogenization Via Subject Weight Knock-down

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Nov 13

PMID 23144770

Authors

Andre X C N Valente

Joseph Zischkau

Joo Heon Shin

Yuan Gao

Abhijit Sarkar

Affiliations

Soon will be listed here.

Abstract

Population structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy phenotype ratio across the cohort, by decreasing the statistical weight of selected individuals. After homogenization, the cohort is statistically handled as if originating from a single well-mixed population. The method was applied to homogenize a Parkinson's disease genome-wide association study cohort.

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