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PDF-1 Neuropeptide Signaling Modulates a Neural Circuit for Mate-searching Behavior in C. Elegans

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Journal Nat Neurosci
Date 2012 Nov 13
PMID 23143519
Citations 69
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Abstract

Appetitive behaviors require complex decision making that involves the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food and reproductive appetite. We found that the pigment dispersing factor receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive that promotes male exploration following mate deprivation. PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in the hermaphrodite. pdf-1 was required in the gender-shared interneuron AIM, and the receptor acted in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1 and pdfr-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling is involved in regulating motivational internal states.

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References
1.
Kleemann G, Jia L, Emmons S . Regulation of Caenorhabditis elegans male mate searching behavior by the nuclear receptor DAF-12. Genetics. 2008; 180(4):2111-22. PMC: 2600945. DOI: 10.1534/genetics.108.093773. View

2.
Lipton J, Kleemann G, Ghosh R, Lints R, Emmons S . Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrate. J Neurosci. 2004; 24(34):7427-34. PMC: 6729642. DOI: 10.1523/JNEUROSCI.1746-04.2004. View

3.
Stewart H, ONeil N, Janke D, Franz N, Chamberlin H, Howell A . Lethal mutations defining 112 complementation groups in a 4.5 Mb sequenced region of Caenorhabditis elegans chromosome III. Mol Gen Genet. 1998; 260(2-3):280-8. DOI: 10.1007/pl00013816. View

4.
Zhang Y, Ma C, Delohery T, Nasipak B, Foat B, Bounoutas A . Identification of genes expressed in C. elegans touch receptor neurons. Nature. 2002; 418(6895):331-5. DOI: 10.1038/nature00891. View

5.
Lee R, Sawin E, Chalfie M, Horvitz H, Avery L . EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in caenorhabditis elegans. J Neurosci. 1998; 19(1):159-67. PMC: 3759158. View