The Social Network of Carbon Monoxide in Medicine

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2012 Nov 13

PMID 23140858

Citations 44

Authors

Barbara Wegiel

Douglas W Hanto

Leo E Otterbein

Affiliations

Soon will be listed here.

Abstract

Networking between cells is critical for proper functioning of the cellular milieu and is mediated by cascades of highly regulated and overlapping signaling molecules. The enzyme heme oxygenase-1 (HO-1) generates three separate signaling molecules through the catalysis of heme - carbon monoxide (CO), biliverdin, and iron - each of which acts via distinct molecular targets to influence cell function, both proximally and distally. This review focuses on state-of-the art developments and insights into the impact of HO-1 and CO on the innate immune response, the effects of which are responsible for an ensemble of functions that help regulate complex immunological responses to bacterial sepsis and ischemia/reperfusion injury. HO-1 exemplifies an evolutionarily conserved system necessary for the cellular milieu to adapt appropriately, function properly, and ensure survival of the organism.

Citing Articles

Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer.

Ghareghomi S, Moosavi-Movahedi F, Saso L, Habibi-Rezaei M, Khatibi A, Hong J Antioxidants (Basel). 2023; 12(3).

PMID: 36978983 PMC: 10044870. DOI: 10.3390/antiox12030735.

Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells.

Canesin G, Feldbrugge L, Wei G, Janovicova L, Janikova M, Csizmadia E iScience. 2022; 25(9):104983.

PMID: 36093061 PMC: 9450142. DOI: 10.1016/j.isci.2022.104983.

Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles.

Yang X, Lu W, Hopper C, Ke B, Wang B Acta Pharm Sin B. 2021; 11(6):1434-1445.

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Carbon Monoxide Suppresses Neointima Formation in Transplant Arteriosclerosis by Inhibiting Vascular Progenitor Cell Differentiation.

Sakihama H, Lee G, Chin B, Csizmadia E, Gallo D, Qi Y Arterioscler Thromb Vasc Biol. 2021; 41(6):1915-1927.

PMID: 33853347 PMC: 8159904. DOI: 10.1161/ATVBAHA.120.315558.

Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury.

Rossi M, Korpak K, Doerfler A, Boudjeltia K Biomedicines. 2021; 9(3).

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