CD8+ T Cell-derived IFN-γ Prevents Infection by a Second Heterologous Virus

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2012 Nov 9

PMID 23136204

Citations 7

Authors

Laura Valentine

Rashaun Potts

Mary Premenko-Lanier

Affiliations

Soon will be listed here.

Abstract

Persistent viral infection is often associated with dysfunctional immune responses against unrelated pathogens. Lymphocytic choriomeningitis virus (LCMV) can establish acute or chronic infections in mice and is widely used as a model for persistent virus infections in humans. Mice infected with LCMV develop a transient defect in Ag-specific immunity against heterologous viral infection. Although it has been proposed that LCMV infection induces an immunosuppressed state within the host, our data show that infected mice successfully clear vaccinia virus through a mechanism that involves CD8(+) T cell-derived IFN-γ. This observation demonstrates that chronic LCMV infection does not impair protective immunity against heterologous viral challenge. Rather, a natural sterilizing immunity is induced following a primary infection that prevents a secondary infection. Our findings suggest a need to re-evaluate current thoughts about the immune suppression that might occur during a persistent infection.

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