Functionalized Cyclopropenes and Methylenecyclopropenes from Dianions of 3-Hydroxymethylcyclopropenes

Overview

Journal Synthesis (Stuttg)

Publisher Thieme

Specialty Chemistry

Date 2012 Nov 6

PMID 23125466

Authors

Matthew D Hassink

Joseph M Fox

Affiliations

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Abstract

1,2-Disubstituted-3-hydroxymethylcyclopropene derivatives have been synthesized by reacting the dianions of 1-alkyl-3-hydroxymethylcyclopropenes with a range of electrophiles. Additionally, a complementary procedure is described for one-pot sequential alkylation/rearrangement to provide a convenient synthesis of a chiral methylenecyclopropane directly from a 1-alkyl-3-hydroxymethylcyclopropene.

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