Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora Hydrophyllacea

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2012 Nov 3

PMID 23118716

Citations 14

Authors

Wen-Li Mei

Bo Zheng

You-Xing Zhao

Hui-Ming Zhong

Xun-Li Wu Chen

Yan-Bo Zeng

Wen-Hua Dong

Jiu-Li Huang

Peter Proksch

Hao-Fu Dai

Affiliations

Soon will be listed here.

Abstract

Four new meroterpenes, guignardones F-I (1-4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1-6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.

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References

Zheng B, Zeng Y, Dai H, Zuo W, Guo Z, Yang T . Two new meroterpenes from endophytic fungus A1 of Scyphiphora hydrophyllacea. J Asian Nat Prod Res. 2012; 14(8):776-9. DOI: 10.1080/10286020.2012.693078. View

Zeng Y, Wang H, Zuo W, Zheng B, Yang T, Dai H . A fatty acid glycoside from a marine-derived fungus isolated from mangrove plant Scyphiphora hydrophyllacea. Mar Drugs. 2012; 10(3):598-603. PMC: 3347017. DOI: 10.3390/md10030598. View

Feng C, Gong M, Zeng Y, Dai H, Mei W . Scyphiphin C, a new iridoid from Scyphiphora hydrophyllacea. Molecules. 2010; 15(4):2473-7. PMC: 6257393. DOI: 10.3390/molecules15042473. View

Zeng Y, Mei W, Wang H, Li X, Dai H . Scyphiphin D, a new iridoid glucoside dimer from Scyphiphora hydrophyllacea. J Asian Nat Prod Res. 2010; 12(11):1010-4. DOI: 10.1080/10286020.2010.522181. View

Molinar E, Rios N, Spadafora C, Arnold A, Coley P, Kursar T . Coibanoles, a new class of meroterpenoids produced by . Tetrahedron Lett. 2014; 53(8):919-922. PMC: 4148033. DOI: 10.1016/j.tetlet.2011.12.021. View