Thymidine Phosphorylase Gene Expression in Stage III Colorectal Cancer

Overview

Journal Clin Med Insights Oncol

Publisher Sage Publications

Specialty Oncology

Date 2012 Nov 2

PMID 23115484

Citations 3

Authors

Elinor B Lindskog

Yvonne Wettergren

Elisabeth Odin

Bengt Gustavsson

Kristoffer Derwinger

Affiliations

Soon will be listed here.

Abstract

Background: The thymidine phosphorylase (TP) enzyme has several tumor-promoting functions. The aim of this study was to explore TP gene expression in relation to clinical and histopathological data obtained from patients with stage III colorectal cancer.

Methods And Results: TP gene expression was analyzed by real-time quantitative PCR in tumor and mucosa samples from 254 patients. TP gene expression in tumors correlated with lymph node staging, with higher expression relating to a higher number of positive nodes and a worse N-stage. Higher TP expression was also associated with a worse histological tumor grade. Patients with rectal cancer had significantly higher TP expression in mucosa and tumors compared with patients having colon cancer.

Conclusion: Higher intratumoral TP expression appears to be related to a worse N stage, and thus, with a worse prognosis. TP gene expression measured in a preoperative biopsy could be of interest in preoperative staging.

Citing Articles

Impact of thymidine phosphorylase and CD163 expression on prognosis in stage II colorectal cancer.

Kaidi D, Szeponik L, Yrlid U, Wettergren Y, Bexe Lindskog E Clin Transl Oncol. 2022; 24(9):1818-1827.

PMID: 35567733 PMC: 9338131. DOI: 10.1007/s12094-022-02839-2.

Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment.

Azwar S, Seow H, Abdullah M, Jabar M, Mohtarrudin N Biology (Basel). 2021; 10(9).

PMID: 34571731 PMC: 8466833. DOI: 10.3390/biology10090854.

Thymidine phosphorylase expression is associated with time to progression in patients with metastatic colorectal cancer.

Bexe Lindskog E, Derwinger K, Gustavsson B, Falk P, Wettergren Y BMC Clin Pathol. 2014; 14:25.

PMID: 24936150 PMC: 4058433. DOI: 10.1186/1472-6890-14-25.

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