Cellular and Intracellular Mechanisms Involved in the Cognitive Impairment of Cannabinoids

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2012 Oct 31

PMID 23108544

Citations 44

Authors

Emma Puighermanal

Arnau Busquets-Garcia

Rafael Maldonado

Andres Ozaita

Affiliations

Soon will be listed here.

Abstract

Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.

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