Serum Copper in Alzheimer's Disease and Vascular Dementia

Overview

Journal Indian J Clin Biochem

Specialty Biochemistry

Date 2012 Oct 30

PMID 23105789

Citations 8

Authors

Rachna Agarwal

Suman S Kushwaha

C B Tripathi

Neeraj Singh

Neelam Chhillar

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease is the most common form of dementia in the elderly and it's prevalence is rapidly rising. Oxidative stress plays important role in the pathophysiology of Alzheimer's disease. Metals like copper, iron derived through diet can act as pro-oxidant under oxidative stress. In the present study, serum copper levels were evaluated in 50 patients with Alzheimer's disease, 24 patients with Vascular Dementia and 30 controls. All the groups were also investigated for serum ceruloplsmin levels. The mean copper levels in Alzheimer's disease and Vascular Dementia were significantly raised compared to controls. An attempt has been made to study the relationship of serum copper with ceruloplasmin. Our study found weak correlation between copper and ceruloplasmin levels in Alzheimer's disease and Vascular Dementia.

Citing Articles

Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis.

Philbert S, Xu J, Church S, Unwin R, Roncaroli F, Cooper G Front Aging Neurosci. 2022; 14:926463.

PMID: 35923550 PMC: 9340791. DOI: 10.3389/fnagi.2022.926463.

The Associations of Dietary Copper With Cognitive Outcomes.

Wei J, Gianattasio K, Bennett E, Stewart J, Xu X, Park E Am J Epidemiol. 2022; 191(7):1202-1211.

PMID: 35238336 PMC: 9890213. DOI: 10.1093/aje/kwac040.

Copper Imbalance in Alzheimer's Disease: Meta-Analysis of Serum, Plasma, and Brain Specimens, and Replication Study Evaluating Gene Variants.

Squitti R, Ventriglia M, Simonelli I, Bonvicini C, Costa A, Perini G Biomolecules. 2021; 11(7).

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Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies.

Patwa J, Flora S Int J Mol Sci. 2020; 21(11).

PMID: 32485831 PMC: 7313017. DOI: 10.3390/ijms21113862.

Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies.

Li D, Zhang W, Wang Z, Zhao P Front Aging Neurosci. 2017; 9:300.

PMID: 28966592 PMC: 5605551. DOI: 10.3389/fnagi.2017.00300.

References

Pullen R, Franklin P, Hall G . 65Zn uptake from blood into brain in the rat. J Neurochem. 1991; 56(2):485-9. DOI: 10.1111/j.1471-4159.1991.tb08176.x. View

Squitti R, Lupoi D, Pasqualetti P, Forno G, Vernieri F, Chiovenda P . Elevation of serum copper levels in Alzheimer's disease. Neurology. 2002; 59(8):1153-61. DOI: 10.1212/wnl.59.8.1153. View

Bush A . The metallobiology of Alzheimer's disease. Trends Neurosci. 2003; 26(4):207-14. DOI: 10.1016/S0166-2236(03)00067-5. View

Huang X, Cuajungco M, Atwood C, Hartshorn M, Tyndall J, Hanson G . Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem. 1999; 274(52):37111-6. DOI: 10.1074/jbc.274.52.37111. View

Gonzalez C, Martin T, Cacho J, Brenas M, Arroyo T, Navajo J . Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers. Eur J Clin Invest. 1999; 29(7):637-42. DOI: 10.1046/j.1365-2362.1999.00471.x. View

Markesbery W . Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med. 1997; 23(1):134-47. DOI: 10.1016/s0891-5849(96)00629-6. View

Lovell M, ROBERTSON J, Teesdale W, Campbell J, Markesbery W . Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci. 1998; 158(1):47-52. DOI: 10.1016/s0022-510x(98)00092-6. View

Squitti R, Rossini P, Cassetta E, Moffa F, Pasqualetti P, Cortesi M . d-penicillamine reduces serum oxidative stress in Alzheimer's disease patients. Eur J Clin Invest. 2002; 32(1):51-9. DOI: 10.1046/j.1365-2362.2002.00933.x. View

Huang X, Atwood C, Hartshorn M, Multhaup G, Goldstein L, Scarpa R . The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 1999; 38(24):7609-16. DOI: 10.1021/bi990438f. View

10.

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34(7):939-44. DOI: 10.1212/wnl.34.7.939. View

11.

Ozcankaya R, Delibas N . Malondialdehyde, superoxide dismutase, melatonin, iron, copper, and zinc blood concentrations in patients with Alzheimer disease: cross-sectional study. Croat Med J. 2002; 43(1):28-32. View

12.

Cuajungco M, Faget K, Huang X, Tanzi R, Bush A . Metal chelation as a potential therapy for Alzheimer's disease. Ann N Y Acad Sci. 2001; 920:292-304. DOI: 10.1111/j.1749-6632.2000.tb06938.x. View

13.

Squitti R, Pasqualetti P, Cassetta E, Forno G, Cesaretti S, Pedace F . Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia. Neurology. 2003; 60(12):2013-4. DOI: 10.1212/01.wnl.0000068013.27968.29. View

14.

Pratico D, Uryu K, Leight S, Trojanoswki J, Lee V . Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci. 2001; 21(12):4183-7. PMC: 6762743. View

15.

Kontush A, Berndt C, Weber W, Akopyan V, Arlt S, Schippling S . Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma. Free Radic Biol Med. 2001; 30(1):119-28. DOI: 10.1016/s0891-5849(00)00458-5. View

16.

Johnson P, Milne D, Lykken G . Effects of age and sex on copper absorption, biological half-life, and status in humans. Am J Clin Nutr. 1992; 56(5):917-25. DOI: 10.1093/ajcn/56.5.917. View

17.

Abe A, Yamashita S, Noma A . Sensitive, direct colorimetric assay for copper in serum. Clin Chem. 1989; 35(4):552-4. View

18.

Sayre L, Perry G, Harris P, Liu Y, Schubert K, Smith M . In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. J Neurochem. 2000; 74(1):270-9. DOI: 10.1046/j.1471-4159.2000.0740270.x. View

19.

Zou K, Gong J, Yanagisawa K, Michikawa M . A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage. J Neurosci. 2002; 22(12):4833-41. PMC: 6757724. View

20.

Pullen R, Franklin P, Hall G . 65zinc uptake from blood into brain and other tissues in the rat. Neurochem Res. 1990; 15(10):1003-8. DOI: 10.1007/BF00965746. View