Sialic Acid in Cardiovascular Diseases

Overview

Journal Indian J Clin Biochem

Specialty Biochemistry

Date 2012 Oct 30

PMID 23105570

Citations 16

Authors

P K Nigam

V S Narain

Ajay Kumar

Affiliations

Soon will be listed here.

Abstract

Sialic acid, the acylated derivatives of 9-carbon sugar neuraminic acid, present as terminal component of oligosaccharide chains of many glycoproteins and glycolipids, has been recognized to be involved in the regulation of a great variety of biological phenomena. Studies have shown that serum sialic acid predicts both coronary heart disease and stroke mortality and reflects the existence or activity of an atherosclerotic process. Most of the studies have shown an elevation in serum sialic acid concentration in coronary heart disease and a positive correlation between the raised serum sialic acid and the severity of the coronary lesions is observed. However, a few contradictory reports are also available. Racial differences in serum sialic acid have also been reported and correlated with international differences in the prevalence of atherosclerosis. Reduced sialic acid content of platelets, erythrocytes and lipoproteins may play important role in the pathogenesis of atherosclerosis. Elucidation of the mechanism of alternation in sialic acid concentration may throw more light on its potential clinical utility. Hence more studies are needed to designates sialic acid as a cardiovascular risk factor/marker.

Citing Articles

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References

Cohen N, Ekholm J, Luthra M, HANAHAN D . Biochemical characterization of density-separated human erythrocytes. Biochim Biophys Acta. 1976; 419(2):229-42. DOI: 10.1016/0005-2736(76)90349-7. View

Pickup J, Mattock M . Activation of the innate immune system as a predictor of cardiovascular mortality in Type 2 diabetes mellitus. Diabet Med. 2003; 20(9):723-6. DOI: 10.1046/j.1464-5491.2003.00990.x. View

Kruth H . The fate of lipoprotein cholesterol entering the arterial wall. Curr Opin Lipidol. 1997; 8(5):246-52. DOI: 10.1097/00041433-199710000-00002. View

Resnitzky P, Yaari A, Danon D . Biophysical characteristics of erythrocytes during acute myocardial infarction and venous thrombosis. Thromb Diath Haemorrh. 1972; 28(3):524-32. View

Orekhov A, Tertov V, Mukhin D, Mikhailenko I . Modification of low density lipoprotein by desialylation causes lipid accumulation in cultured cells: discovery of desialylated lipoprotein with altered cellular metabolism in the blood of atherosclerotic patients. Biochem Biophys Res Commun. 1989; 162(1):206-11. DOI: 10.1016/0006-291x(89)91982-7. View

Venerando B, Fiorilli A, Croci G, Tringali C, Goi G, Mazzanti L . Acidic and neutral sialidase in the erythrocyte membrane of type 2 diabetic patients. Blood. 2002; 99(3):1064-70. DOI: 10.1182/blood.v99.3.1064. View

Sprague E, Moser M, Edwards E, Schwartz C . Stimulation of receptor-mediated low density lipoprotein endocytosis in neuraminidase-treated cultured bovine aortic endothelial cells. J Cell Physiol. 1988; 137(2):251-62. DOI: 10.1002/jcp.1041370207. View

Wakabayashi I, Sakamoto K, Yoshimoto S, Masui H . Relation of serum sialic acid to lipid concentrations. BMJ. 1992; 305(6853):562-3. PMC: 1883271. DOI: 10.1136/bmj.305.6853.562. View

Haq M, Haq S, Tutt P, Crook M . Serum total sialic acid and lipid-associated sialic acid in normal individuals and patients with myocardial infarction, and their relationship to acute phase proteins. Ann Clin Biochem. 1993; 30 ( Pt 4):383-6. DOI: 10.1177/000456329303000406. View

10.

Tertov V, Sobenin I, Gabbasov Z, Popov E, Jaakkola O, Solakivi T . Multiple-modified desialylated low density lipoproteins that cause intracellular lipid accumulation. Isolation, fractionation and characterization. Lab Invest. 1992; 67(5):665-75. View

11.

Seaman G, Vassar P . Changes in the electrokinetic properties of platelets during their aggregation. Arch Biochem Biophys. 1966; 117(1):10-7. DOI: 10.1016/0003-9861(66)90119-6. View

12.

Hadengue A, Razavian S, Del-Pino M, Simon A, Levenson J . Influence of sialic acid on erythrocyte aggregation in hypercholesterolemia. Thromb Haemost. 1996; 76(6):944-9. View

13.

Pyorala K, Laakso M, Uusitupa M . Diabetes and atherosclerosis: an epidemiologic view. Diabetes Metab Rev. 1987; 3(2):463-524. DOI: 10.1002/dmr.5610030206. View

14.

MALMENDIER C, Delcroix C, Fontaine M . Effect of sialic acid removal on human low density lipoprotein catabolism in vivo. Atherosclerosis. 1980; 37(2):277-84. DOI: 10.1016/0021-9150(80)90013-1. View

15.

Crook M, Lumb P, Andrews V, Swaminathan R . Serum total sialic acid, a reputed cardiovascular risk factor, and its relationship to lipids, plasma fasting insulin, blood pressure and body mass index in normal individuals. Clin Sci (Lond). 1998; 95(1):53-7. DOI: 10.1042/cs0950053. View

16.

Schauer R . Chemistry, metabolism, and biological functions of sialic acids. Adv Carbohydr Chem Biochem. 1982; 40:131-234. DOI: 10.1016/s0065-2318(08)60109-2. View

17.

Chappey B, Myara I, Giral P, Kerharo G, PLAINFOSSE M, Levenson J . Evaluation of the sialic acid content of LDL as a marker of coronary calcification and extracoronary atherosclerosis in asymptomatic hypercholesterolemic subjects. PCVMETRA Group. Arterioscler Thromb Vasc Biol. 1995; 15(3):334-9. DOI: 10.1161/01.atv.15.3.334. View

18.

Filipovic I, Buddecke E . Desialized low-density lipoprotein regulates cholesterol metabolism in receptor-deficient fibroblasts. Eur J Biochem. 1979; 101(1):119-22. DOI: 10.1111/j.1432-1033.1979.tb04223.x. View

19.

Gattegno L, Perret G, Fabia F, CORNILLOT P . Decrease of carbohydrate in membrane glycoproteins during human erythrocyte ageing in vivo. Mech Ageing Dev. 1981; 16(3):205-19. DOI: 10.1016/0047-6374(81)90097-x. View

20.

Sillanaukee P, Ponnio M, Jaaskelainen I . Occurrence of sialic acids in healthy humans and different disorders. Eur J Clin Invest. 1999; 29(5):413-25. DOI: 10.1046/j.1365-2362.1999.00485.x. View