An Efficient Synthesis of Novel Dispirooxindole Derivatives Via One-pot Three-component 1,3-dipolar Cycloaddition Reactions

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2012 Oct 30

PMID 23103534

Citations 3

Authors

Zhibin Huang

Qian Zhao

Gang Chen

Huiyuan Wang

Wei Lin

Lexing Xu

Hongtao Liu

Juxian Wang

Daqing Shi

Yucheng Wang

Affiliations

Soon will be listed here.

Abstract

A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.

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